Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044778822> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2044778822 endingPage "S19" @default.
- W2044778822 startingPage "S15" @default.
- W2044778822 abstract "Side-effects of antipsychotic treatment are important factors in patients' compliance with treatment regimens. Of particular relevance to compliance are extrapyramidal symptoms (EPS), sedation, weight gain and sexual dysfunction. The new, atypical antipsychotics offer several tolerability benefits over conventional neuroleptics, particularly with respect to EPS. However, differences in their receptor binding characteristics result in different side-effect profiles. All novel antipsychotics have a high 5-HT2 to D2 receptor binding ratio, which is postulated to be important for a low liability for EPS. Ziprasidone, a new antipsychotic in the late stages of clinical development, has a low affinity for some receptor types, activation of which has been linked with adverse events such as sedation, postural hypotension, weight gain and cognitive impairment; for example, ziprasidone has minimal activity at muscarinic (M1), histaminergic (H1) and α1-adrenergic receptors. In short- and long-term clinical trials, ziprasidone had a low liability for side-effects typically associated with poor compliance, such as EPS, weight gain and sexual dysfunction. The tolerability profiles of the new antipsychotics represent a major improvement over the older neuroleptics. The more favourable the benefit/risk ratios of these new drugs throughout all phases of treatment, the greater the likelihood that patients will have better outcomes." @default.
- W2044778822 created "2016-06-24" @default.
- W2044778822 creator A5030503062 @default.
- W2044778822 date "2001-01-01" @default.
- W2044778822 modified "2023-10-18" @default.
- W2044778822 title "Barriers to progress-the impact of tolerability problems" @default.
- W2044778822 cites W122505910 @default.
- W2044778822 cites W1966155579 @default.
- W2044778822 cites W1983133139 @default.
- W2044778822 cites W1988730265 @default.
- W2044778822 cites W2007865301 @default.
- W2044778822 cites W2014598223 @default.
- W2044778822 cites W2061276728 @default.
- W2044778822 cites W2140936735 @default.
- W2044778822 cites W2154849243 @default.
- W2044778822 doi "https://doi.org/10.1097/00004850-200101001-00004" @default.
- W2044778822 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11252523" @default.
- W2044778822 hasPublicationYear "2001" @default.
- W2044778822 type Work @default.
- W2044778822 sameAs 2044778822 @default.
- W2044778822 citedByCount "18" @default.
- W2044778822 countsByYear W20447788222015 @default.
- W2044778822 countsByYear W20447788222017 @default.
- W2044778822 crossrefType "journal-article" @default.
- W2044778822 hasAuthorship W2044778822A5030503062 @default.
- W2044778822 hasConcept C118552586 @default.
- W2044778822 hasConcept C126322002 @default.
- W2044778822 hasConcept C15744967 @default.
- W2044778822 hasConcept C197934379 @default.
- W2044778822 hasConcept C2776412080 @default.
- W2044778822 hasConcept C2776921671 @default.
- W2044778822 hasConcept C2777270317 @default.
- W2044778822 hasConcept C2778093883 @default.
- W2044778822 hasConcept C2778375690 @default.
- W2044778822 hasConcept C2780494398 @default.
- W2044778822 hasConcept C2780616385 @default.
- W2044778822 hasConcept C71924100 @default.
- W2044778822 hasConcept C98274493 @default.
- W2044778822 hasConceptScore W2044778822C118552586 @default.
- W2044778822 hasConceptScore W2044778822C126322002 @default.
- W2044778822 hasConceptScore W2044778822C15744967 @default.
- W2044778822 hasConceptScore W2044778822C197934379 @default.
- W2044778822 hasConceptScore W2044778822C2776412080 @default.
- W2044778822 hasConceptScore W2044778822C2776921671 @default.
- W2044778822 hasConceptScore W2044778822C2777270317 @default.
- W2044778822 hasConceptScore W2044778822C2778093883 @default.
- W2044778822 hasConceptScore W2044778822C2778375690 @default.
- W2044778822 hasConceptScore W2044778822C2780494398 @default.
- W2044778822 hasConceptScore W2044778822C2780616385 @default.
- W2044778822 hasConceptScore W2044778822C71924100 @default.
- W2044778822 hasConceptScore W2044778822C98274493 @default.
- W2044778822 hasIssue "Supplement 1" @default.
- W2044778822 hasLocation W20447788221 @default.
- W2044778822 hasLocation W20447788222 @default.
- W2044778822 hasOpenAccess W2044778822 @default.
- W2044778822 hasPrimaryLocation W20447788221 @default.
- W2044778822 hasRelatedWork W1816035024 @default.
- W2044778822 hasRelatedWork W1975179169 @default.
- W2044778822 hasRelatedWork W1987765077 @default.
- W2044778822 hasRelatedWork W2044778822 @default.
- W2044778822 hasRelatedWork W2062588862 @default.
- W2044778822 hasRelatedWork W2088052920 @default.
- W2044778822 hasRelatedWork W2105507333 @default.
- W2044778822 hasRelatedWork W2111083453 @default.
- W2044778822 hasRelatedWork W4302765522 @default.
- W2044778822 hasRelatedWork W2131271269 @default.
- W2044778822 hasVolume "16" @default.
- W2044778822 isParatext "false" @default.
- W2044778822 isRetracted "false" @default.
- W2044778822 magId "2044778822" @default.
- W2044778822 workType "article" @default.