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- W2044804490 abstract "In this study, we have investigated the role of albumin in zinc-induced neurotoxicity of cultured rat cerebellar granule neurons. ZnCl2 induces cerebellar granule cell death in a time- and concentration-dependent manner and albumin in serum affords a significant protection against zinc-induced neurotoxicity. We further measured intracellular zinc concentrations in the presence or absence of albumin. The results showed that exogenously added ZnCl2 induced an increase in intracellular zinc concentrations in a concentration-dependent fashion in albumin-free buffer. However, in the presence of albumin, it dramatically decreased ZnCl2-induced elevation of intracellular zinc concentrations. These results indicate that albumin protects against zinc-induced neurotoxicity by blocking extracellular zinc uptake by neurons." @default.
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- W2044804490 date "2005-09-08" @default.
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- W2044804490 title "Albumin protects cultured cerebellar granule neurons against zinc neurotoxicity" @default.
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- W2044804490 doi "https://doi.org/10.1097/01.wnr.0000176523.34594.98" @default.
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