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• W2044807909 abstract "High drug attrition rates due to toxicity, the controversy of experimental animal usage, and the EU REACH regulation demanding toxicity profiles of a high number of chemicals demonstrate the need for new, in vitro toxicity models with high predictivity and throughput. Metabolism by cytochrome P450s (P450s) is one of the main causes of drug toxicity. As some of these enzymes are highly polymorphic leading to large differences is metabolic capacity, isotype-specific test systems are needed. In this review, we will discuss the use of yeast expressing (mammalian) P450s as a powerful, additional model system in drug safety. We will discuss the various cellular model systems for bioactivation-related toxicity and subsequently describe the properties of yeast as a model system, including the endogenous bioactivation enzymes present, the heterologous expression of (mammalian) P450s and the application of yeasts expressing heterologous P450s and/or other biotransformation enzymes in toxicity studies. All major human drug-metabolizing P450s have been successfully expressed in yeast and various mutagenicity tests have been performed with these humanized yeast strains. The few examples of non-mutagenic toxicity studies with these strains and of the combination of P450s with phase II or other human enzymes show the potential of yeast as a model system in metabolism-related toxicity studies. The wide variety of genome-wide screens available in yeast, combined with its well-annotated genome, also facilitate follow-up studies on the genes involved in toxicity. Unless indicated otherwise “yeast” will refer to baker’s yeast Saccharomyces cerevisiae. Keywords: Biotransformation, cytochrome P450 metabolism, model systems, yeast" @default.
• W2044807909 created "2016-06-24" @default.
• W2044807909 creator A5027199677 @default.
• W2044807909 creator A5027247735 @default.
• W2044807909 creator A5076536725 @default.
• W2044807909 date "2012-10-01" @default.
• W2044807909 modified "2023-10-14" @default.
• W2044807909 title "Yeast as a Humanized Model Organism for Biotransformation-Related Toxicity" @default.
• W2044807909 cites W1508115080 @default.
• W2044807909 cites W1511946771 @default.
• W2044807909 cites W1517027332 @default.
• W2044807909 cites W1810878477 @default.
• W2044807909 cites W1850243065 @default.
• W2044807909 cites W1889516833 @default.
• W2044807909 cites W1895993106 @default.
• W2044807909 cites W1965259050 @default.
• W2044807909 cites W1968872516 @default.
• W2044807909 cites W1969653503 @default.
• W2044807909 cites W1970069945 @default.
• W2044807909 cites W1974004653 @default.
• W2044807909 cites W1974933116 @default.
• W2044807909 cites W1975912619 @default.
• W2044807909 cites W1977677201 @default.
• W2044807909 cites W1978120003 @default.
• W2044807909 cites W1979105963 @default.
• W2044807909 cites W1979328799 @default.
• W2044807909 cites W1980657599 @default.
• W2044807909 cites W1980829113 @default.
• W2044807909 cites W1983352128 @default.
• W2044807909 cites W1986580547 @default.
• W2044807909 cites W1987184539 @default.
• W2044807909 cites W1987380471 @default.
• W2044807909 cites W1987588369 @default.
• W2044807909 cites W1991206583 @default.
• W2044807909 cites W1991241185 @default.
• W2044807909 cites W1991586824 @default.
• W2044807909 cites W1992389633 @default.
• W2044807909 cites W1998375609 @default.
• W2044807909 cites W2001385355 @default.
• W2044807909 cites W2006287364 @default.
• W2044807909 cites W2008774977 @default.
• W2044807909 cites W2009191320 @default.
• W2044807909 cites W2012121552 @default.
• W2044807909 cites W2013233393 @default.
• W2044807909 cites W2013611909 @default.
• W2044807909 cites W2014031830 @default.
• W2044807909 cites W2014501746 @default.
• W2044807909 cites W2014569937 @default.
• W2044807909 cites W2015788935 @default.
• W2044807909 cites W2017995274 @default.
• W2044807909 cites W2019756631 @default.
• W2044807909 cites W2023998653 @default.
• W2044807909 cites W2027254129 @default.
• W2044807909 cites W2029754131 @default.
• W2044807909 cites W2029967286 @default.
• W2044807909 cites W2030819538 @default.
• W2044807909 cites W2030863517 @default.
• W2044807909 cites W2031060899 @default.
• W2044807909 cites W2031070002 @default.
• W2044807909 cites W2031172417 @default.
• W2044807909 cites W2031628031 @default.
• W2044807909 cites W2033195986 @default.
• W2044807909 cites W2033605818 @default.
• W2044807909 cites W2036068456 @default.
• W2044807909 cites W2036185485 @default.
• W2044807909 cites W2036873731 @default.
• W2044807909 cites W2039677216 @default.
• W2044807909 cites W2041063545 @default.
• W2044807909 cites W2041160885 @default.
• W2044807909 cites W2044241207 @default.
• W2044807909 cites W2047525305 @default.
• W2044807909 cites W2048565186 @default.
• W2044807909 cites W2049548112 @default.
• W2044807909 cites W2050155922 @default.
• W2044807909 cites W2050444538 @default.
• W2044807909 cites W2054469848 @default.
• W2044807909 cites W2055449385 @default.
• W2044807909 cites W2055665277 @default.
• W2044807909 cites W2057620040 @default.
• W2044807909 cites W2058624667 @default.
• W2044807909 cites W2059269436 @default.
• W2044807909 cites W2059700063 @default.
• W2044807909 cites W2061298521 @default.
• W2044807909 cites W2062376995 @default.
• W2044807909 cites W2062398703 @default.
• W2044807909 cites W2062441368 @default.
• W2044807909 cites W2065901895 @default.
• W2044807909 cites W2066072558 @default.
• W2044807909 cites W2070550165 @default.
• W2044807909 cites W2072010935 @default.
• W2044807909 cites W2072398397 @default.
• W2044807909 cites W2073642561 @default.
• W2044807909 cites W2074958386 @default.
• W2044807909 cites W2075362447 @default.
• W2044807909 cites W2076186508 @default.
• W2044807909 cites W2077128388 @default.
• W2044807909 cites W2077860506 @default.
• W2044807909 cites W2079433226 @default.

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