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- W2044814887 abstract "The availability of glatiramer acetate (GA) for inducing immune tolerance is a significant advancement in the treatment of multiple sclerosis (MS). However, a sizable proportion of patients maintain active disease, regardless of treatment. Another approach to induce T-cell tolerance is therefore still an unmet medical need. We hypothesized that induction of mucosal tolerance toward a pro-inflammatory T-cell epitope derived from a heat shock protein (HSP) (RatP2) could translate into clinical benefit. We found that treatment of experimental autoimmune encephalomyelitis (EAE, a model of MS) with the peptide RatP2 determined a significant clinical improvement, which was comparable to the standard tolerization treatment (an MBP-derived peptide pool) and superior to GA. Histological analysis demonstrated a reduction of brain and spinal cord inflammatory lesions in treated animals. Moreover, with immunological analysis we identified biomarkers associated with clinical response. This work provides proof-of-concept to support the further testing of this approach as a possible complement to currently available therapies for MS." @default.
- W2044814887 created "2016-06-24" @default.
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- W2044814887 date "2012-11-01" @default.
- W2044814887 modified "2023-10-18" @default.
- W2044814887 title "Epitope-specific immune tolerization ameliorates experimental autoimmune encephalomyelitis" @default.
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- W2044814887 doi "https://doi.org/10.1016/j.clim.2012.08.004" @default.
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