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• W2044821204 startingPage "1019" @default.
• W2044821204 abstract "At 4 wk after intraperitoneal inoculation of murine cytomegalovirus (MCMV) in adult BALB/c mice, MCMV remained detectable only in the salivary glands. When T cells of these mice were activated by a single injection of anti-CD3 epsilon monoclonal antibody, mice died of interstitial pneumonitis at 24-48 h after injection, accompanied by elevation of serum levels of TNF-alpha and IFN-gamma. However, MCMV remained undetectable in the lungs during the period. Simultaneous injection of cyclosporin A reduced such effects of anti-CD3. In conclusion, although the presence of MCMV in the host may be required, MCMV-associated pneumonitis is not mediated by virus in the lung but probably by the cytokines released from T cells, of which responsiveness to stimulation via CD3 molecule has been presumably modified by MCMV infection." @default.
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• W2044821204 date "1994-09-01" @default.
• W2044821204 modified "2023-10-14" @default.
• W2044821204 title "Murine cytomegalovirus-associated pneumonitis in the lungs free of the virus." @default.
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• W2044821204 doi "https://doi.org/10.1172/jci117415" @default.
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