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- W2044844516 abstract "Curves for the survival of reproductive capacity of explanted human tumor cells, following exposure to the alkylating agent nitrogen mustard (mustine hydrochloride) or 250-kVp x rays, were obtained as soon as a satisfactory plating efficiency, i.e., greater than or approximately equal to 10 percent, was obtained from the tumor cells in vitro (usually within 2-10 weeks of explanation). It was found that all six tumor explants tested became more sensitive to the action of nitrogen mustard on serial subculture, whereas the response of four explants which were X-irradiated was invariant with further subculturing. Furthermore, all but one explant yielded survival curves which were extremely similar, with D/sub q/ values circa 440-610 rad. One line, from a seminoma, however, had a D/sub q/ of 150 rad. These radiosensitive seminoma cells were, however, the most resistant to the action of nitrogen mustard. The increase in sensitivity to nitrogen mustard with serial subculture in vitro was not associated with any change in the proliferative rate of the cells, although it may be associated with an increase in the efficiency of transport." @default.
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- W2044844516 date "1977-01-01" @default.
- W2044844516 modified "2023-09-23" @default.
- W2044844516 title "Reproductive Survival of Explanted Human Tumor Cells after Exposure to Nitrogen Mustard or X Irradiation; Differences in Response with Subsequent Subculture in Vitro" @default.
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- W2044844516 doi "https://doi.org/10.2307/3574520" @default.
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