FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044846385> ?p ?o ?g. }

• W2044846385 endingPage "47" @default.
• W2044846385 startingPage "139" @default.
• W2044846385 abstract "A critical issue concerning Alzheimer's disease is its selectivity, which leads to cellular degeneration in certain brain areas but not in others, and whether this pathogenic selectivity involves products of the amyloid precursor protein (APP). Here, we show that the amyloid beta protein Abeta1-42 is accumulated gradually and is retained intact by field CA1, but not by other subdivisions, of organotypic hippocampal slice cultures. In contrast, the slightly shorter Abeta1-40 peptide was not sequestered selectively. Sequestration of Abeta1-42 was followed by the build-up of carboxyterminal fragments of the endogenous precursor protein that were identified by immunoprecipitation. Unlike the peptide uptake, this induction appeared to be stochastic at the cellular level. In addition, the APP fragments were distributed more broadly within the CA1 pyramidal neurons than the sequestered Abeta1-42, and they appeared to be localized to synaptic terminals in the molecular layer of the dentate gyrus and in the stratum lacunosum-moleculare of the subfield CA3. Concentrations of synaptophysin, a presynaptic marker, decreased as the number of neurons producing amyloidogenic species increased. These results indicate that exogenous Abeta1-42 sets into motion a sequence that involves 1) selective uptake of the peptide by vulnerable cells at risk in Alzheimer's disease, 2) markedly enhanced production of amyloidogenic precursor material, and 3) slow deterioration of central synapses." @default.
• W2044846385 created "2016-06-24" @default.
• W2044846385 creator A5020704914 @default.
• W2044846385 creator A5059306142 @default.
• W2044846385 creator A5074348666 @default.
• W2044846385 creator A5077330153 @default.
• W2044846385 creator A5079367953 @default.
• W2044846385 creator A5089219708 @default.
• W2044846385 date "1998-07-20" @default.
• W2044846385 modified "2023-10-17" @default.
• W2044846385 title "Amyloid beta protein is internalized selectively by hippocampal field CA1 and causes neurons to accumulate amyloidogenic carboxyterminal fragments of the amyloid precursor protein." @default.
• W2044846385 cites W1486013008 @default.
• W2044846385 cites W1502820594 @default.
• W2044846385 cites W1539232350 @default.
• W2044846385 cites W1554824558 @default.
• W2044846385 cites W1919811763 @default.
• W2044846385 cites W1967237003 @default.
• W2044846385 cites W1972094490 @default.
• W2044846385 cites W1974028432 @default.
• W2044846385 cites W1977683347 @default.
• W2044846385 cites W1980225806 @default.
• W2044846385 cites W1980433009 @default.
• W2044846385 cites W1980906872 @default.
• W2044846385 cites W1985514882 @default.
• W2044846385 cites W1995515835 @default.
• W2044846385 cites W1997410519 @default.
• W2044846385 cites W2001327864 @default.
• W2044846385 cites W2011424449 @default.
• W2044846385 cites W2021753155 @default.
• W2044846385 cites W2032073915 @default.
• W2044846385 cites W2033382511 @default.
• W2044846385 cites W2036288989 @default.
• W2044846385 cites W2039005734 @default.
• W2044846385 cites W2039170442 @default.
• W2044846385 cites W2047815983 @default.
• W2044846385 cites W2057530634 @default.
• W2044846385 cites W2058110454 @default.
• W2044846385 cites W2061761983 @default.
• W2044846385 cites W2063013822 @default.
• W2044846385 cites W2064820088 @default.
• W2044846385 cites W2067811915 @default.
• W2044846385 cites W2069479156 @default.
• W2044846385 cites W2071390704 @default.
• W2044846385 cites W2073397630 @default.
• W2044846385 cites W2075875770 @default.
• W2044846385 cites W2077845591 @default.
• W2044846385 cites W2078365752 @default.
• W2044846385 cites W2079054696 @default.
• W2044846385 cites W2079580304 @default.
• W2044846385 cites W2081881251 @default.
• W2044846385 cites W2082504479 @default.
• W2044846385 cites W2084338110 @default.
• W2044846385 cites W2091334591 @default.
• W2044846385 cites W2095180840 @default.
• W2044846385 cites W2101077392 @default.
• W2044846385 cites W2108689038 @default.
• W2044846385 cites W2117037463 @default.
• W2044846385 cites W2120236371 @default.
• W2044846385 cites W2130144581 @default.
• W2044846385 cites W2137695170 @default.
• W2044846385 cites W2149579301 @default.
• W2044846385 cites W2166681711 @default.
• W2044846385 cites W2764814173 @default.
• W2044846385 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9671284" @default.
• W2044846385 hasPublicationYear "1998" @default.
• W2044846385 type Work @default.
• W2044846385 sameAs 2044846385 @default.
• W2044846385 citedByCount "40" @default.
• W2044846385 countsByYear W20448463852012 @default.
• W2044846385 countsByYear W20448463852013 @default.
• W2044846385 countsByYear W20448463852014 @default.
• W2044846385 countsByYear W20448463852015 @default.
• W2044846385 countsByYear W20448463852016 @default.
• W2044846385 countsByYear W20448463852018 @default.
• W2044846385 countsByYear W20448463852019 @default.
• W2044846385 countsByYear W20448463852021 @default.
• W2044846385 countsByYear W20448463852022 @default.
• W2044846385 countsByYear W20448463852023 @default.
• W2044846385 crossrefType "journal-article" @default.
• W2044846385 hasAuthorship W2044846385A5020704914 @default.
• W2044846385 hasAuthorship W2044846385A5059306142 @default.
• W2044846385 hasAuthorship W2044846385A5074348666 @default.
• W2044846385 hasAuthorship W2044846385A5077330153 @default.
• W2044846385 hasAuthorship W2044846385A5079367953 @default.
• W2044846385 hasAuthorship W2044846385A5089219708 @default.
• W2044846385 hasConcept C126322002 @default.
• W2044846385 hasConcept C148762608 @default.
• W2044846385 hasConcept C169760540 @default.
• W2044846385 hasConcept C177907266 @default.
• W2044846385 hasConcept C179104552 @default.
• W2044846385 hasConcept C185592680 @default.
• W2044846385 hasConcept C203014093 @default.
• W2044846385 hasConcept C204232928 @default.
• W2044846385 hasConcept C2776156579 @default.
• W2044846385 hasConcept C2776464000 @default.
• W2044846385 hasConcept C2777209535 @default.
• W2044846385 hasConcept C2777633098 @default.
• W2044846385 hasConcept C2778670691 @default.

• next