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• W2044846885 endingPage "9562" @default.
• W2044846885 startingPage "9553" @default.
• W2044846885 abstract "Activity-dependent long-term synaptic plasticity requires gene expression and protein synthesis. Identifying essential genes and studying their transcriptional and translational regulation are key steps to understanding how synaptic changes become long lasting. Recently, the enzyme poly-(ADP-ribose) polymerase 1 (PARP-1) was shown to be necessary for long-term memory (LTM) in Aplysia . Since PARP-1 decondenses chromatin, we hypothesize that this enzyme regulates the expression of specific genes essential for long-term synaptic plasticity that underlies LTM. We cloned Aplysia PARP-1 ( ApPARP-1 ) and determined that its expression in sensory neurons is necessary for serotonin (5-HT)-mediated long-term facilitation (LTF) of sensorimotor neuron synapses. PARP enzymatic activity is also required, since transient application of PARP inhibitors blocked LTF. Differential display and RNA analysis of ganglia dissected from intact animals exposed to 5-HT identified the ribosomal RNA genes as PARP-dependent effector genes. The increase in the expression of rRNAs is long lasting and dynamic. Pulse-labeling RNA studies showed a PARP-dependent increase in rRNAs but not in the total RNA 24 h after 5-HT treatment. Moreover, the expression of both the AprpL27a ( Aplysia ribosomal protein L27a) and the ApE2N ( Aplysia ubiquitin-conjugating enzyme E2N) mRNAs also increased after 5-HT. Thus, our results suggest that 5-HT, in part by regulating PARP-1 activity, alters the expression of transcripts required for the synthesis of new ribosomes necessary for LTF." @default.
• W2044846885 created "2016-06-24" @default.
• W2044846885 creator A5009797504 @default.
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• W2044846885 date "2009-07-29" @default.
• W2044846885 modified "2023-10-04" @default.
• W2044846885 title "Poly-(ADP-Ribose) Polymerase-1 Is Necessary for Long-Term Facilitation in<i>Aplysia</i>" @default.
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• W2044846885 doi "https://doi.org/10.1523/jneurosci.1512-09.2009" @default.
• W2044846885 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6666525" @default.
• W2044846885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19641118" @default.
• W2044846885 hasPublicationYear "2009" @default.
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