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• W2044851963 endingPage "e57957" @default.
• W2044851963 startingPage "e57957" @default.
• W2044851963 abstract "Repetitive transcranial magnetic stimulation (rTMS) of the human motor hand area (M1HAND) can induce lasting changes in corticospinal excitability as indexed by a change in amplitude of the motor-evoked potential. The plasticity-inducing effects of rTMS in M1HAND show substantial inter-individual variability which has been partially attributed to the val66met polymorphism in the brain-derived neurotrophic factor (BDNF) gene. Here we used theta burst stimulation (TBS) to examine whether the BDNF val66met genotype can be used to predict the expression of TBS-induced homeostatic metaplasticity in human M1HAND. TBS is a patterned rTMS protocol with intermittent TBS (iTBS) usually inducing a lasting increase and continuous TBS (cTBS) a lasting decrease in corticospinal excitability. In three separate sessions, healthy val66met (n = 12) and val66val (n = 17) carriers received neuronavigated cTBS followed by cTBS (n = 27), cTBS followed by iTBS (n = 29), and iTBS followed by iTBS (n = 28). Participants and examiner were blinded to the genotype at the time of examination. As expected, the first TBS intervention induced a decrease (cTBS) and increase (iTBS) in corticospinal excitability, respectively, at the same time priming the after effects caused by the second TBS intervention in a homeostatic fashion. Critically, val66met carriers and val66val carriers showed very similar response patterns to cTBS and iTBS regardless of the order of TBS interventions. Since none of the observed TBS effects was modulated by the BDNF val66met polymorphism, our results do not support the notion that the BDNF val66met genotype is a major player with regard to TBS-induced plasticity and metaplasticity in the human M1HAND." @default.
• W2044851963 created "2016-06-24" @default.
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• W2044851963 date "2013-02-28" @default.
• W2044851963 modified "2023-10-01" @default.
• W2044851963 title "Brain-Derived Neurotrophic Factor – A Major Player in Stimulation-Induced Homeostatic Metaplasticity of Human Motor Cortex?" @default.
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• W2044851963 doi "https://doi.org/10.1371/journal.pone.0057957" @default.
• W2044851963 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3585283" @default.
• W2044851963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23469118" @default.
• W2044851963 hasPublicationYear "2013" @default.
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