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• W2044853621 startingPage "153" @default.
• W2044853621 abstract "Intact zebrafish embryos were used as an <I>in vivo</I> animal model to investigate the role of Ca<SUP>2+</SUP> signaling during the differentiation of slow muscle cells (SMCs) within forming skeletal muscle. Transgenic zebrafish were generated using an a-actin promoter that targeted apoaequorin expression specifically to muscle cells. Two distinct Ca<SUP>2+</SUP> signaling periods (CSPs) were visualized in the developing SMCs: between ~17.5-19.5 hours post-fertilization (hpf) and after ~23 hpf, separated by a ~3.5 h Ca<SUP>2+</SUP> signaling quiet period. Further spatial characterization of these Ca2+ signals using confocal fluorescent microscopy and calcium green-1 dextran as a reporter, indicated that the earlier CSP displayed distinct nuclear and cytoplasmic components, whereas the later CSP was predominantly cytoplasmic. Both CSPs consisted of a series of oscillating Ca<SUP>2+</SUP> waves generated at distinct frequencies, while the earlier CSP also displayed a slow rise then fall in the Ca<SUP>2+</SUP> baseline-level. Imaging of cyclopamine- and forskolin-treated wild-type, or <I>smo<SUP>-/-</SUP></I> mutant embryos, where SMCs do not form, confirmed the specific cell population generating the signals. Treating embryos with antagonists indicated that both IP<SUB>3</SUB>Rs and RyRs are responsible for generating the temporal characteristics of the Ca<SUP>2+</SUP> signaling signature, and that the latter plays a necessary role in SMC differentiation and subsequent myotome patterning. Together, these data support and extend the proposition that specific spatiotemporal patterns of spontaneous Ca<SUP>2+</SUP> signals might be used for different as well as combinatorial regulation of both nuclear and cytosolic signal transduction cascades, resulting in myofibrillogenesis in SMCs as well as myotome patterning." @default.
• W2044853621 created "2016-06-24" @default.
• W2044853621 creator A5023898239 @default.
• W2044853621 creator A5053226187 @default.
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• W2044853621 date "2011-01-01" @default.
• W2044853621 modified "2023-09-25" @default.
• W2044853621 title "Visualization, characterization and modulation of calcium signaling during the development of slow muscle cells in intact zebrafish embryos" @default.
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• W2044853621 doi "https://doi.org/10.1387/ijdb.103160cc" @default.
• W2044853621 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21553383" @default.
• W2044853621 hasPublicationYear "2011" @default.
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