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- W2044865722 abstract "Abstract In order to obtain more information about the application of polyamino acids as high molecular weight carriers of mitomycin C (MMC), conjugates with the polyamino acids: poly- l -glutamic acid (PGA; mol. wt. 11,000 and 60,000), poly- l -aspartic acid (PAA; mol. wt. 14,000) and poly- l -lysine (PLY; mol. wt. 13,000) were synthesized. Some physicochemical and antitumor characteristics of these conjugates were investigated. Gel filtration confirmed covalent binding and provided information about the molecular sizes. The release rates of MMC from conjugates were determined in vitro. The PAA and PGA (mol. wt. 11,000) conjugates acted as negatively charged molecules in their interaction with ion exchangers. The PLY conjugate showed a positive charge and was able to bind to Ehrlich Ascites Carcinoma cells in vitro. The effects of 1 h exposure of mouse L1210 leukemia cells to the conjugates were evaluated using cell culture system. In this experiment, only the PLY conjugate showed better effects than MMC. Continuous exposure to the conjugates showed a similar effect to MMC. In vivo, less toxicity was found for the conjugates than for MMC. The PGA (mol. wt. 11,000) and PLY conjugates showed slightly higher effects against P388 leukemia than MMC, while no toxic doses were reached." @default.
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- W2044865722 date "1984-11-01" @default.
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- W2044865722 title "Physicochemical and antitumor characteristics of some polyamino acid prodrugs of mitomycin C" @default.
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- W2044865722 doi "https://doi.org/10.1016/0378-5173(84)90047-4" @default.
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