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- W2044876560 endingPage "367" @default.
- W2044876560 startingPage "349" @default.
- W2044876560 abstract "The integrity of the human genome is constantly threatened by genotoxic agents that cause DNA damage. Inefficient or inaccurate repair of DNA lesions triggers genome instability and can lead to cancer development or even cell death. Cells counteract the adverse effects of DNA lesions by activating the DNA damage response (DDR), which entails a coordinated series of events that regulates cell cycle progression and repair of DNA lesions. Efficient DNA repair in living cells is complicated by the packaging of genomic DNA into a condensed, often inaccessible structure called chromatin. Cells utilize post-translational histone modifications and ATP-dependent chromatin remodeling to modulate chromatin structure and increase the accessibility of the repair machinery to lesions embedded in chromatin. Here we review and discuss our current knowledge and recent advances on DNA damage-induced chromatin changes and their implications for the mammalian DNA damage response, genome stability and carcinogenesis. Exploiting our improving understanding of how modulators of chromatin structure orchestrate the DDR may provide new avenues to improve cancer management." @default.
- W2044876560 created "2016-06-24" @default.
- W2044876560 creator A5002710740 @default.
- W2044876560 creator A5091679060 @default.
- W2044876560 date "2011-07-03" @default.
- W2044876560 modified "2023-10-03" @default.
- W2044876560 title "Chromatin and the DNA damage response: The cancer connection" @default.
- W2044876560 cites W1538419182 @default.
- W2044876560 cites W174577041 @default.
- W2044876560 cites W1914441096 @default.
- W2044876560 cites W1965249701 @default.
- W2044876560 cites W1965582387 @default.
- W2044876560 cites W1966383291 @default.
- W2044876560 cites W1968516742 @default.
- W2044876560 cites W1970680779 @default.
- W2044876560 cites W1971848700 @default.
- W2044876560 cites W1971857971 @default.
- W2044876560 cites W1971868237 @default.
- W2044876560 cites W1973030224 @default.
- W2044876560 cites W1973268287 @default.
- W2044876560 cites W1974327959 @default.
- W2044876560 cites W1974755980 @default.
- W2044876560 cites W1974795717 @default.
- W2044876560 cites W1975660840 @default.
- W2044876560 cites W1976242374 @default.
- W2044876560 cites W1977434752 @default.
- W2044876560 cites W1978660434 @default.
- W2044876560 cites W1978727518 @default.
- W2044876560 cites W1978780879 @default.
- W2044876560 cites W1982657419 @default.
- W2044876560 cites W1987849582 @default.
- W2044876560 cites W1989800108 @default.
- W2044876560 cites W1989829234 @default.
- W2044876560 cites W1995569417 @default.
- W2044876560 cites W1996243898 @default.
- W2044876560 cites W1997029250 @default.
- W2044876560 cites W1997303368 @default.
- W2044876560 cites W1997576768 @default.
- W2044876560 cites W1998499862 @default.
- W2044876560 cites W1999541392 @default.
- W2044876560 cites W2000342325 @default.
- W2044876560 cites W2006001474 @default.
- W2044876560 cites W2008162481 @default.
- W2044876560 cites W2008650297 @default.
- W2044876560 cites W2008686279 @default.
- W2044876560 cites W2008738118 @default.
- W2044876560 cites W2009007206 @default.
- W2044876560 cites W2009403023 @default.
- W2044876560 cites W2010383327 @default.
- W2044876560 cites W2013427348 @default.
- W2044876560 cites W2013826273 @default.
- W2044876560 cites W2014179038 @default.
- W2044876560 cites W2018458310 @default.
- W2044876560 cites W2019637656 @default.
- W2044876560 cites W2020084014 @default.
- W2044876560 cites W2021565943 @default.
- W2044876560 cites W2021606478 @default.
- W2044876560 cites W2022529531 @default.
- W2044876560 cites W2023853131 @default.
- W2044876560 cites W2028222949 @default.
- W2044876560 cites W2029005510 @default.
- W2044876560 cites W2030748126 @default.
- W2044876560 cites W2031203839 @default.
- W2044876560 cites W2032739040 @default.
- W2044876560 cites W2033172828 @default.
- W2044876560 cites W2034195501 @default.
- W2044876560 cites W2034718433 @default.
- W2044876560 cites W2035924891 @default.
- W2044876560 cites W2036158314 @default.
- W2044876560 cites W2038451572 @default.
- W2044876560 cites W2038649631 @default.
- W2044876560 cites W2039143648 @default.
- W2044876560 cites W2040249690 @default.
- W2044876560 cites W2041613483 @default.
- W2044876560 cites W2042480414 @default.
- W2044876560 cites W2042962536 @default.
- W2044876560 cites W2043895957 @default.
- W2044876560 cites W2045493291 @default.
- W2044876560 cites W2046329243 @default.
- W2044876560 cites W2046691617 @default.
- W2044876560 cites W2050949546 @default.
- W2044876560 cites W2052130151 @default.
- W2044876560 cites W2052289985 @default.
- W2044876560 cites W2056679680 @default.
- W2044876560 cites W2057626539 @default.
- W2044876560 cites W2058471321 @default.
- W2044876560 cites W2058655256 @default.
- W2044876560 cites W2059059097 @default.
- W2044876560 cites W2060870400 @default.
- W2044876560 cites W2063851753 @default.
- W2044876560 cites W2064256444 @default.
- W2044876560 cites W2064297857 @default.
- W2044876560 cites W2066664553 @default.
- W2044876560 cites W2068030382 @default.
- W2044876560 cites W2068973408 @default.
- W2044876560 cites W2069328568 @default.
- W2044876560 cites W2070312499 @default.
- W2044876560 cites W2070582215 @default.