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• W2044878334 startingPage "5684" @default.
• W2044878334 abstract "We have identified a series of diphenylmethylene hydroxamic acids as novel and selective HDAC class IIa inhibitors. The original hit, N-hydroxy-2,2-diphenylacetamide (6), has sub-micromolar class IIa HDAC inhibitory activity, while the rigidified oxygen analogue, N-hydroxy-9H-xanthene-9-carboxamide (13), is slightly more selective for HDAC7 with an IC50 of 0.05 μM. Substitution of 6 allows for the modulation of selectivity and potency amongst the class IIa HDAC isotypes." @default.
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• W2044878334 date "2009-10-01" @default.
• W2044878334 modified "2023-09-27" @default.
• W2044878334 title "Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors" @default.
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• W2044878334 doi "https://doi.org/10.1016/j.bmcl.2009.08.010" @default.
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