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- W2044884889 endingPage "99" @default.
- W2044884889 startingPage "83" @default.
- W2044884889 abstract "Apoptosis mediated via extrinsic or intrinsic pathways is essential for maintaining cellular homeostasis in the liver. The extrinsic pathway is triggered from the cell surface by engagement of death receptors as CD95, TRAIL (TNF-related apoptosis inducing ligand) and TNF (tumour necrosis factor) or TGF-β (transforming growth factor beta) receptors. The intrinsic pathway is initiated from the mitochondria and can be influenced by Bcl-2 family members. Both pathways are intertwined and play a physiological role in the liver. Dysregulation of apoptosis pathways contributes to diseases as hepatocellular carcinoma, viral hepatitis, autoimmune hepatitis, ischaemia–reperfusion injury, iron or copper deposition disorders, toxic liver damage and acute liver failure. The apoptosis defects are often central pathogenetic events; hence molecular mechanisms of apoptosis give not only insight into disease mechanisms but also provide potential corresponding therapeutic candidates in liver disease. The focus of this review is the identification of apoptotic signalling components in the liver as therapeutic targets." @default.
- W2044884889 created "2016-06-24" @default.
- W2044884889 creator A5074321844 @default.
- W2044884889 date "2005-02-01" @default.
- W2044884889 modified "2023-09-25" @default.
- W2044884889 title "Modulation of apoptosis as a target for liver disease" @default.
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