FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044887735> ?p ?o ?g. }

• W2044887735 endingPage "14251" @default.
• W2044887735 startingPage "14243" @default.
• W2044887735 abstract "The gastrointestinal (GI) tract presents a major site of immune modulation by HIV, resulting in significant morbidity. Most GI processes affected during HIV infection are regulated by the enteric nervous system. HIV has been identified in GI histologic specimens in up to 40% of patients, and the presence of viral proteins, including the trans-activator of transcription (Tat), has been reported in the gut indicating that HIV itself may be an indirect gut pathogen. Little is known of how Tat affects the enteric nervous system. Here we investigated the effects of the Tat protein on enteric neuronal excitability, proinflammatory cytokine release, and its overall effect on GI motility. Direct application of Tat (100 nm) increased the number of action potentials and reduced the threshold for action potential initiation in isolated myenteric neurons. This effect persisted in neurons pretreated with Tat for 3 d (19 of 20) and in neurons isolated from Tat(+) (Tat-expressing) transgenic mice. Tat increased sodium channel isoforms Nav1.7 and Nav1.8 levels. This increase was accompanied by an increase in sodium current density and a leftward shift in the sodium channel activation voltage. RANTES, IL-6, and IL-1β, but not TNF-α, were enhanced by Tat. Intestinal transit and cecal water content were also significantly higher in Tat(+) transgenic mice than Tat(-) littermates (controls). Together, these findings show that Tat has a direct and persistent effect on enteric neuronal excitability, and together with its effect on proinflammatory cytokines, regulates gut motility, thereby contributing to GI dysmotilities reported in HIV patients." @default.
• W2044887735 created "2016-06-24" @default.
• W2044887735 creator A5000297941 @default.
• W2044887735 creator A5002137270 @default.
• W2044887735 creator A5010070535 @default.
• W2044887735 creator A5021216149 @default.
• W2044887735 creator A5024918594 @default.
• W2044887735 creator A5030189017 @default.
• W2044887735 creator A5032088201 @default.
• W2044887735 creator A5076458805 @default.
• W2044887735 creator A5084533103 @default.
• W2044887735 date "2014-10-22" @default.
• W2044887735 modified "2023-10-14" @default.
• W2044887735 title "Effects of HIV-1 Tat on Enteric Neuropathogenesis" @default.
• W2044887735 cites W1516887940 @default.
• W2044887735 cites W1522340644 @default.
• W2044887735 cites W1543084458 @default.
• W2044887735 cites W190913331 @default.
• W2044887735 cites W1913367972 @default.
• W2044887735 cites W1963544479 @default.
• W2044887735 cites W1966156553 @default.
• W2044887735 cites W1973535106 @default.
• W2044887735 cites W1976434061 @default.
• W2044887735 cites W1979953377 @default.
• W2044887735 cites W1984999783 @default.
• W2044887735 cites W1988363221 @default.
• W2044887735 cites W1990457915 @default.
• W2044887735 cites W1993264471 @default.
• W2044887735 cites W1995254193 @default.
• W2044887735 cites W1996476108 @default.
• W2044887735 cites W1998529637 @default.
• W2044887735 cites W2003545714 @default.
• W2044887735 cites W2005087194 @default.
• W2044887735 cites W2008994596 @default.
• W2044887735 cites W2010358244 @default.
• W2044887735 cites W2014964914 @default.
• W2044887735 cites W2016117860 @default.
• W2044887735 cites W2018207369 @default.
• W2044887735 cites W2019602756 @default.
• W2044887735 cites W2032722583 @default.
• W2044887735 cites W2033185924 @default.
• W2044887735 cites W2035872135 @default.
• W2044887735 cites W2036505093 @default.
• W2044887735 cites W2049015703 @default.
• W2044887735 cites W2051664921 @default.
• W2044887735 cites W2054869385 @default.
• W2044887735 cites W2058983339 @default.
• W2044887735 cites W2059095114 @default.
• W2044887735 cites W2060064384 @default.
• W2044887735 cites W2060407010 @default.
• W2044887735 cites W2064265086 @default.
• W2044887735 cites W2077157308 @default.
• W2044887735 cites W2084251620 @default.
• W2044887735 cites W2087423729 @default.
• W2044887735 cites W2087693617 @default.
• W2044887735 cites W2088571422 @default.
• W2044887735 cites W2095083924 @default.
• W2044887735 cites W2111392394 @default.
• W2044887735 cites W2116994155 @default.
• W2044887735 cites W2126812377 @default.
• W2044887735 cites W2131180540 @default.
• W2044887735 cites W2133775325 @default.
• W2044887735 cites W2135817676 @default.
• W2044887735 cites W2138902434 @default.
• W2044887735 cites W2141966120 @default.
• W2044887735 cites W2144722464 @default.
• W2044887735 cites W2145464880 @default.
• W2044887735 cites W2148570600 @default.
• W2044887735 cites W2150484278 @default.
• W2044887735 cites W2150871111 @default.
• W2044887735 cites W2154774779 @default.
• W2044887735 cites W2155134319 @default.
• W2044887735 cites W2162943132 @default.
• W2044887735 cites W2165232112 @default.
• W2044887735 cites W2293877091 @default.
• W2044887735 cites W2413479299 @default.
• W2044887735 doi "https://doi.org/10.1523/jneurosci.2283-14.2014" @default.
• W2044887735 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4205550" @default.
• W2044887735 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25339738" @default.
• W2044887735 hasPublicationYear "2014" @default.
• W2044887735 type Work @default.
• W2044887735 sameAs 2044887735 @default.
• W2044887735 citedByCount "30" @default.
• W2044887735 countsByYear W20448877352015 @default.
• W2044887735 countsByYear W20448877352016 @default.
• W2044887735 countsByYear W20448877352017 @default.
• W2044887735 countsByYear W20448877352018 @default.
• W2044887735 countsByYear W20448877352019 @default.
• W2044887735 countsByYear W20448877352020 @default.
• W2044887735 countsByYear W20448877352021 @default.
• W2044887735 countsByYear W20448877352022 @default.
• W2044887735 countsByYear W20448877352023 @default.
• W2044887735 crossrefType "journal-article" @default.
• W2044887735 hasAuthorship W2044887735A5000297941 @default.
• W2044887735 hasAuthorship W2044887735A5002137270 @default.
• W2044887735 hasAuthorship W2044887735A5010070535 @default.
• W2044887735 hasAuthorship W2044887735A5021216149 @default.
• W2044887735 hasAuthorship W2044887735A5024918594 @default.

• next