Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044893048> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2044893048 endingPage "836" @default.
- W2044893048 startingPage "831" @default.
- W2044893048 abstract "Loss of the G1/S checkpoint is recognized as a mandatory step in the development of cancer. Nevertheless, both in vivo and in vitro experiments have indicated that this condition highly sensitizes cells to apoptosis, e.g., primary mouse embryonic fibroblasts that lack the complete retinoblastoma suppressor gene family (TKO MEFs) massively die under mitogen-deprived conditions. The prevailing hypothesis therefore is that the increased proliferative capacity of cells that have lost the G1/S checkpoint becomes apparent by suppression of apoptosis. However, this view was recently challenged by the finding that suppression of apoptotic cell death in TKO MEFs did not allow unconstrained proliferation; instead, cells became arrested in G2. This mechanism, which is dependent on p53, provides yet another barrier to oncogenic transformation. Thus, progression to malignancy of Rb-deficient lesions by alleviation of G2 arrest may offer an alternative explanation for the synergism between loss of Rb and p53 in tumorigenesis." @default.
- W2044893048 created "2016-06-24" @default.
- W2044893048 creator A5002551113 @default.
- W2044893048 creator A5090303159 @default.
- W2044893048 date "2006-04-03" @default.
- W2044893048 modified "2023-10-13" @default.
- W2044893048 title "Check, Double Check: The G2 Barrier to Cancer" @default.
- W2044893048 doi "https://doi.org/10.4161/cc.5.8.2687" @default.
- W2044893048 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16627998" @default.
- W2044893048 hasPublicationYear "2006" @default.
- W2044893048 type Work @default.
- W2044893048 sameAs 2044893048 @default.
- W2044893048 citedByCount "43" @default.
- W2044893048 countsByYear W20448930482012 @default.
- W2044893048 countsByYear W20448930482013 @default.
- W2044893048 countsByYear W20448930482014 @default.
- W2044893048 countsByYear W20448930482015 @default.
- W2044893048 countsByYear W20448930482016 @default.
- W2044893048 countsByYear W20448930482017 @default.
- W2044893048 countsByYear W20448930482019 @default.
- W2044893048 countsByYear W20448930482023 @default.
- W2044893048 crossrefType "journal-article" @default.
- W2044893048 hasAuthorship W2044893048A5002551113 @default.
- W2044893048 hasAuthorship W2044893048A5090303159 @default.
- W2044893048 hasBestOaLocation W20448930481 @default.
- W2044893048 hasConcept C104317684 @default.
- W2044893048 hasConcept C105696609 @default.
- W2044893048 hasConcept C121608353 @default.
- W2044893048 hasConcept C145103041 @default.
- W2044893048 hasConcept C179185449 @default.
- W2044893048 hasConcept C190283241 @default.
- W2044893048 hasConcept C2776062698 @default.
- W2044893048 hasConcept C2776577112 @default.
- W2044893048 hasConcept C2778264664 @default.
- W2044893048 hasConcept C29537977 @default.
- W2044893048 hasConcept C31573885 @default.
- W2044893048 hasConcept C50001416 @default.
- W2044893048 hasConcept C502942594 @default.
- W2044893048 hasConcept C54355233 @default.
- W2044893048 hasConcept C555283112 @default.
- W2044893048 hasConcept C86803240 @default.
- W2044893048 hasConcept C95444343 @default.
- W2044893048 hasConcept C96232424 @default.
- W2044893048 hasConceptScore W2044893048C104317684 @default.
- W2044893048 hasConceptScore W2044893048C105696609 @default.
- W2044893048 hasConceptScore W2044893048C121608353 @default.
- W2044893048 hasConceptScore W2044893048C145103041 @default.
- W2044893048 hasConceptScore W2044893048C179185449 @default.
- W2044893048 hasConceptScore W2044893048C190283241 @default.
- W2044893048 hasConceptScore W2044893048C2776062698 @default.
- W2044893048 hasConceptScore W2044893048C2776577112 @default.
- W2044893048 hasConceptScore W2044893048C2778264664 @default.
- W2044893048 hasConceptScore W2044893048C29537977 @default.
- W2044893048 hasConceptScore W2044893048C31573885 @default.
- W2044893048 hasConceptScore W2044893048C50001416 @default.
- W2044893048 hasConceptScore W2044893048C502942594 @default.
- W2044893048 hasConceptScore W2044893048C54355233 @default.
- W2044893048 hasConceptScore W2044893048C555283112 @default.
- W2044893048 hasConceptScore W2044893048C86803240 @default.
- W2044893048 hasConceptScore W2044893048C95444343 @default.
- W2044893048 hasConceptScore W2044893048C96232424 @default.
- W2044893048 hasIssue "8" @default.
- W2044893048 hasLocation W20448930481 @default.
- W2044893048 hasLocation W20448930482 @default.
- W2044893048 hasOpenAccess W2044893048 @default.
- W2044893048 hasPrimaryLocation W20448930481 @default.
- W2044893048 hasRelatedWork W1506786556 @default.
- W2044893048 hasRelatedWork W1975618936 @default.
- W2044893048 hasRelatedWork W2013603496 @default.
- W2044893048 hasRelatedWork W2044893048 @default.
- W2044893048 hasRelatedWork W2065255444 @default.
- W2044893048 hasRelatedWork W2084401359 @default.
- W2044893048 hasRelatedWork W2327359575 @default.
- W2044893048 hasRelatedWork W2407332484 @default.
- W2044893048 hasRelatedWork W2551973039 @default.
- W2044893048 hasRelatedWork W2974159611 @default.
- W2044893048 hasVolume "5" @default.
- W2044893048 isParatext "false" @default.
- W2044893048 isRetracted "false" @default.
- W2044893048 magId "2044893048" @default.
- W2044893048 workType "article" @default.