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• W2044893057 abstract "Padlock probes are molecular tools that combine highly specific target sequence recognition with the potential for multiplexed analysis of large sets of target DNA or RNA sequences. In this brief review, we exemplify the ability of these probes to distinguish single-nucleotide target sequence variants. We further discuss means to detect the location of target sequences in situ, and to amplify reacted padlock probes via rolling-circle replication, as well as to sort reaction products on tag-arrays. We argue that the probes have the potential to render high-throughput genetic analyses precise and affordable." @default.
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• W2044893057 date "2002-03-18" @default.
• W2044893057 modified "2023-09-23" @default.
• W2044893057 title "Making ends meet in genetic analysis using padlock probes" @default.
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• W2044893057 doi "https://doi.org/10.1002/humu.10073" @default.
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