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- W2044895959 abstract "It is agreed that nuclear-encoded mitochondrial proteins are post-translationally targeted to mitochondria, even if, in some cases, a co-translational phase can assist the import of precursor proteins. We used yeast DNA microarrays to analyse the mRNA populations associated with free and mitochondrion-bound polysomes. As expected, many mRNAs, known to encode mitochondrial proteins, are localized to free cytoplasmic polysomes, but many are localized to mitochondrion-bound polysomes. Furthermore, the 3'-UTR of six randomly chosen mitochondrion-bound mRNAs contains sufficient information to target, in vivo, non-translatable RNA to the vicinity of mitochondria. Interestingly, genes producing mRNAs that are targeted to mitochondria are mainly of ancient bacterial origin, whereas those producing mRNAs that are translated in the cytoplasm are mainly of eukaryotic origin. These observations, which support the recent hypotheses concerning the dual origin of the mitochondrial proteome, provide new insights into the biogenesis of mitochondria." @default.
- W2044895959 created "2016-06-24" @default.
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- W2044895959 date "2002-02-01" @default.
- W2044895959 modified "2023-10-16" @default.
- W2044895959 title "Genome‐wide analysis of mRNAs targeted to yeast mitochondria" @default.
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- W2044895959 doi "https://doi.org/10.1093/embo-reports/kvf025" @default.
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