Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044903552> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2044903552 endingPage "153" @default.
- W2044903552 startingPage "147" @default.
- W2044903552 abstract "An enantioselective stability-indicating high performance liquid chromatographic method was developed for the analysis of arotinolol in standard solution. The degradation behaviour of arotinolol was investigated under different stress conditions recommended by International Conference on Harmonization (ICH). Resolution of the drug and complete separation from its degradation products were successfully achieved on a Chirobiotic V column, using UV detector set at 315 nm, polar organic mobile phase (POM) consisting of methanol:glacial acetic acid:triethylamine, 100:0.02:0.03, (v/v/v), and a flow rate of 1 ml/min. The drug was subjected to oxidation, hydrolysis, photolysis, and heat to apply stress conditions. The drug was found to degrade in alkaline, acidic, oxidative conditions and when exposed to heat. The drug was stable to sunlight. The method reported here has also been successfully applied to pharmaceutical formulation and to human plasma that spiked with stock solutions of arotinolol enantiomers. Arotinolol enaniomers were recovered from plasma by using liquid–liquid extraction procedure with ethyl ether. The method was highly specific, where degradation products and coformulated compounds did not interfere, and was sensitive with good precision and accuracy and was linear over the range of 50–400 ng/ml (R2 > 0.9981) with a detection limit of 20 ng/ml for each enantiomer. The mean extraction efficiency for arotinolol was in the ranges 96–104% for each enantiomer. The mean relative standard deviation (RSD) of the results of within-day precision and accuracy of the drug were ⩽7.1%. There was no significant difference between inter- and intra-day studies for each enantiomers which confirmed the reproducibility of the assay. The overall recoveries of arotinolol enantiomers from pharmaceutical formulations were in the ranges 97.6–101.8%." @default.
- W2044903552 created "2016-06-24" @default.
- W2044903552 creator A5004481817 @default.
- W2044903552 creator A5021529856 @default.
- W2044903552 creator A5066508769 @default.
- W2044903552 date "2010-07-01" @default.
- W2044903552 modified "2023-09-25" @default.
- W2044903552 title "Chiral stability-indicating HPLC method for analysis of arotinolol in pharmaceutical formulation and human plasma" @default.
- W2044903552 cites W1834511982 @default.
- W2044903552 cites W2006237353 @default.
- W2044903552 cites W2013655441 @default.
- W2044903552 cites W2014218579 @default.
- W2044903552 cites W2017436561 @default.
- W2044903552 cites W2032049920 @default.
- W2044903552 cites W2048384646 @default.
- W2044903552 cites W2049552437 @default.
- W2044903552 cites W2053702188 @default.
- W2044903552 cites W2059096342 @default.
- W2044903552 cites W2076749201 @default.
- W2044903552 cites W2079724543 @default.
- W2044903552 cites W2096803474 @default.
- W2044903552 doi "https://doi.org/10.1016/j.arabjc.2010.04.002" @default.
- W2044903552 hasPublicationYear "2010" @default.
- W2044903552 type Work @default.
- W2044903552 sameAs 2044903552 @default.
- W2044903552 citedByCount "4" @default.
- W2044903552 countsByYear W20449035522012 @default.
- W2044903552 countsByYear W20449035522015 @default.
- W2044903552 countsByYear W20449035522019 @default.
- W2044903552 crossrefType "journal-article" @default.
- W2044903552 hasAuthorship W2044903552A5004481817 @default.
- W2044903552 hasAuthorship W2044903552A5021529856 @default.
- W2044903552 hasAuthorship W2044903552A5066508769 @default.
- W2044903552 hasBestOaLocation W20449035521 @default.
- W2044903552 hasConcept C119128265 @default.
- W2044903552 hasConcept C178790620 @default.
- W2044903552 hasConcept C179998833 @default.
- W2044903552 hasConcept C185592680 @default.
- W2044903552 hasConcept C2777682752 @default.
- W2044903552 hasConcept C2779607525 @default.
- W2044903552 hasConcept C43617362 @default.
- W2044903552 hasConcept C45188465 @default.
- W2044903552 hasConcept C486523 @default.
- W2044903552 hasConceptScore W2044903552C119128265 @default.
- W2044903552 hasConceptScore W2044903552C178790620 @default.
- W2044903552 hasConceptScore W2044903552C179998833 @default.
- W2044903552 hasConceptScore W2044903552C185592680 @default.
- W2044903552 hasConceptScore W2044903552C2777682752 @default.
- W2044903552 hasConceptScore W2044903552C2779607525 @default.
- W2044903552 hasConceptScore W2044903552C43617362 @default.
- W2044903552 hasConceptScore W2044903552C45188465 @default.
- W2044903552 hasConceptScore W2044903552C486523 @default.
- W2044903552 hasIssue "3" @default.
- W2044903552 hasLocation W20449035521 @default.
- W2044903552 hasOpenAccess W2044903552 @default.
- W2044903552 hasPrimaryLocation W20449035521 @default.
- W2044903552 hasRelatedWork W1964259887 @default.
- W2044903552 hasRelatedWork W1998279148 @default.
- W2044903552 hasRelatedWork W2013299392 @default.
- W2044903552 hasRelatedWork W2021792606 @default.
- W2044903552 hasRelatedWork W2032191029 @default.
- W2044903552 hasRelatedWork W2036826355 @default.
- W2044903552 hasRelatedWork W2084062459 @default.
- W2044903552 hasRelatedWork W2155596957 @default.
- W2044903552 hasRelatedWork W2166263961 @default.
- W2044903552 hasRelatedWork W2196125403 @default.
- W2044903552 hasVolume "3" @default.
- W2044903552 isParatext "false" @default.
- W2044903552 isRetracted "false" @default.
- W2044903552 magId "2044903552" @default.
- W2044903552 workType "article" @default.