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• W2044904966 abstract "Uptake of uridine was studied in isolated intestinal epithelial cells of guinea pig. Uptake was not severely influenced by metabolism. Free uridine was accumulated within cells 13-fold. Uptake was saturable with an apparent Km value of 46 microM and a Vmax of 0.9 nmol/mg protein per min. Uracil inhibited uptake only slightly; adenosine, guanosine and cytosine inhibited strongly. Antimycin A and ouabain inhibited almost 90%. If the extracellular Na+ concentration was decreased to 5 mM, the rate of uptake decreased 6.5-fold. The stimulatory effect of Na+ was related to the transmembraneous Na+-gradient. Cells from jejunum transported about 30% faster than cells from ileum. In conclusion, isolated enterocytes of guinea pig posses an active transport system for uridine." @default.
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• W2044904966 date "1984-12-01" @default.
• W2044904966 modified "2023-09-27" @default.
• W2044904966 title "Uridine uptake by isolated intestinal epithelial cells of guinea pig" @default.
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• W2044904966 doi "https://doi.org/10.1016/0167-4889(84)90020-x" @default.
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