FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044921805> ?p ?o ?g. }

• W2044921805 endingPage "1743" @default.
• W2044921805 startingPage "1734" @default.
• W2044921805 abstract "Background —Growth hormone (GH) improves cardiac function in the rat with myocardial infarction, but its effects in a model of primary dilated cardiomyopathy have not been reported. GH effects were examined at early (4 months) and late (10 months) phases of disease in the cardiomyopathic (CM) hamster, and the combination of GH with chronic ACE inhibition was assessed in late-phase heart failure. Methods and Results —CM hamsters (CHF 147 line) at 4 months showed severe systolic left ventricular (LV) dysfunction with normal LV filling pressure, and at 10 months there was more severe systolic as well as diastolic dysfunction with increasing myocardial fibrosis. Recombinant human GH alone for 3 weeks at age 4 months increased LV wall thickness and reduced systolic wall stress without altering diastolic wall stress, whereas at 10 months, wall stress and fractional shortening did not improve. The LV dP/dt max was enhanced at both ages by GH, which at 4 months reflected increased contractility, but at 10 months was most likely caused by elevation of the LV filling pressure. The increasing degree of fibrosis correlated inversely with LV function but was unaffected by GH. In other CM hamsters, high-dose ACE inhibition alone (quinapril), started at 8 months and continued for 11 weeks, improved LV function and inhibited unfavorable remodeling, but the addition of GH for 3 weeks at age 10 months produced increased wall thickness with little additional functional benefit and increased the LV filling pressure and diastolic wall stress. Conclusions —GH treatment alone improved LV dysfunction at 4 months of age in CM hamsters by increasing contractility and reducing wall stress but had few beneficial effects at 10 months in severe LV failure. After chronic ACE inhibition, addition of GH at 10 months had no additional beneficial effects and further increased LV diastolic pressure. These differing effects of GH may relate to the progressive increase of LV fibrosis in the CM hamster." @default.
• W2044921805 created "2016-06-24" @default.
• W2044921805 creator A5026487431 @default.
• W2044921805 creator A5027817472 @default.
• W2044921805 creator A5033696938 @default.
• W2044921805 creator A5036512509 @default.
• W2044921805 creator A5043077923 @default.
• W2044921805 creator A5061116337 @default.
• W2044921805 creator A5087269715 @default.
• W2044921805 date "1999-10-19" @default.
• W2044921805 modified "2023-10-15" @default.
• W2044921805 title "Progressive Cardiac Dysfunction and Fibrosis in the Cardiomyopathic Hamster and Effects of Growth Hormone and Angiotensin-Converting Enzyme Inhibition" @default.
• W2044921805 cites W1985292788 @default.
• W2044921805 cites W2002488523 @default.
• W2044921805 cites W2006192343 @default.
• W2044921805 cites W2014494460 @default.
• W2044921805 cites W2036973081 @default.
• W2044921805 cites W2037737006 @default.
• W2044921805 cites W2040727645 @default.
• W2044921805 cites W2041681001 @default.
• W2044921805 cites W2042860187 @default.
• W2044921805 cites W2043750439 @default.
• W2044921805 cites W2063185826 @default.
• W2044921805 cites W2063355998 @default.
• W2044921805 cites W2104475665 @default.
• W2044921805 cites W2105144228 @default.
• W2044921805 cites W2118488318 @default.
• W2044921805 cites W2119951665 @default.
• W2044921805 cites W2143752759 @default.
• W2044921805 cites W2148046136 @default.
• W2044921805 cites W2329687194 @default.
• W2044921805 cites W2336383135 @default.
• W2044921805 cites W2416363040 @default.
• W2044921805 doi "https://doi.org/10.1161/01.cir.100.16.1734" @default.
• W2044921805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10525494" @default.
• W2044921805 hasPublicationYear "1999" @default.
• W2044921805 type Work @default.
• W2044921805 sameAs 2044921805 @default.
• W2044921805 citedByCount "89" @default.
• W2044921805 countsByYear W20449218052012 @default.
• W2044921805 countsByYear W20449218052013 @default.
• W2044921805 countsByYear W20449218052014 @default.
• W2044921805 countsByYear W20449218052015 @default.
• W2044921805 countsByYear W20449218052016 @default.
• W2044921805 countsByYear W20449218052017 @default.
• W2044921805 countsByYear W20449218052018 @default.
• W2044921805 countsByYear W20449218052019 @default.
• W2044921805 countsByYear W20449218052020 @default.
• W2044921805 countsByYear W20449218052021 @default.
• W2044921805 countsByYear W20449218052022 @default.
• W2044921805 crossrefType "journal-article" @default.
• W2044921805 hasAuthorship W2044921805A5026487431 @default.
• W2044921805 hasAuthorship W2044921805A5027817472 @default.
• W2044921805 hasAuthorship W2044921805A5033696938 @default.
• W2044921805 hasAuthorship W2044921805A5036512509 @default.
• W2044921805 hasAuthorship W2044921805A5043077923 @default.
• W2044921805 hasAuthorship W2044921805A5061116337 @default.
• W2044921805 hasAuthorship W2044921805A5087269715 @default.
• W2044921805 hasBestOaLocation W20449218051 @default.
• W2044921805 hasConcept C111566952 @default.
• W2044921805 hasConcept C126322002 @default.
• W2044921805 hasConcept C134018914 @default.
• W2044921805 hasConcept C164705383 @default.
• W2044921805 hasConcept C27016395 @default.
• W2044921805 hasConcept C2776992270 @default.
• W2044921805 hasConcept C2778198053 @default.
• W2044921805 hasConcept C2778271984 @default.
• W2044921805 hasConcept C2778797674 @default.
• W2044921805 hasConcept C2779611605 @default.
• W2044921805 hasConcept C2780559512 @default.
• W2044921805 hasConcept C3018763269 @default.
• W2044921805 hasConcept C3018791406 @default.
• W2044921805 hasConcept C39133596 @default.
• W2044921805 hasConcept C500558357 @default.
• W2044921805 hasConcept C57900726 @default.
• W2044921805 hasConcept C71924100 @default.
• W2044921805 hasConcept C84393581 @default.
• W2044921805 hasConceptScore W2044921805C111566952 @default.
• W2044921805 hasConceptScore W2044921805C126322002 @default.
• W2044921805 hasConceptScore W2044921805C134018914 @default.
• W2044921805 hasConceptScore W2044921805C164705383 @default.
• W2044921805 hasConceptScore W2044921805C27016395 @default.
• W2044921805 hasConceptScore W2044921805C2776992270 @default.
• W2044921805 hasConceptScore W2044921805C2778198053 @default.
• W2044921805 hasConceptScore W2044921805C2778271984 @default.
• W2044921805 hasConceptScore W2044921805C2778797674 @default.
• W2044921805 hasConceptScore W2044921805C2779611605 @default.
• W2044921805 hasConceptScore W2044921805C2780559512 @default.
• W2044921805 hasConceptScore W2044921805C3018763269 @default.
• W2044921805 hasConceptScore W2044921805C3018791406 @default.
• W2044921805 hasConceptScore W2044921805C39133596 @default.
• W2044921805 hasConceptScore W2044921805C500558357 @default.
• W2044921805 hasConceptScore W2044921805C57900726 @default.
• W2044921805 hasConceptScore W2044921805C71924100 @default.
• W2044921805 hasConceptScore W2044921805C84393581 @default.
• W2044921805 hasIssue "16" @default.
• W2044921805 hasLocation W20449218051 @default.
• W2044921805 hasLocation W20449218052 @default.

• next