Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044923404> ?p ?o ?g. }
- W2044923404 endingPage "3323" @default.
- W2044923404 startingPage "3315" @default.
- W2044923404 abstract "Thirty five selenocyanate and diselenide compounds were subjected to in vitro screening against Leishmania infantum promastigotes and the most active ones were also tested in an axenic amastigote model. In order to establish the selectivity indexes (SI) the cytotoxic effect of each compound was also assayed against Jurkat and THP-1 cell lines. Thirteen derivatives exhibit better IC50 values than miltefosine and edelfosine. Bis(4-aminophenyl)diselenide exhibits the best activity when assayed in infected macrophages and one of the lowest cytotoxic activities against the human cell lines tested, with SI values of 32 and 24 against Jurkat and THP-1 cells, respectively. This compound thus represents a new lead for further studies aimed at establishing its mechanism of action." @default.
- W2044923404 created "2016-06-24" @default.
- W2044923404 creator A5011301639 @default.
- W2044923404 creator A5015045226 @default.
- W2044923404 creator A5063979460 @default.
- W2044923404 creator A5064844460 @default.
- W2044923404 creator A5068988240 @default.
- W2044923404 creator A5076267766 @default.
- W2044923404 creator A5080650553 @default.
- W2044923404 date "2011-08-01" @default.
- W2044923404 modified "2023-10-10" @default.
- W2044923404 title "Selenocyanates and diselenides: A new class of potent antileishmanial agents" @default.
- W2044923404 cites W1510568816 @default.
- W2044923404 cites W1964015938 @default.
- W2044923404 cites W1969351587 @default.
- W2044923404 cites W1970594670 @default.
- W2044923404 cites W1973488859 @default.
- W2044923404 cites W1981968564 @default.
- W2044923404 cites W1986370482 @default.
- W2044923404 cites W1988767431 @default.
- W2044923404 cites W2016806358 @default.
- W2044923404 cites W2018716448 @default.
- W2044923404 cites W2025625911 @default.
- W2044923404 cites W2038307493 @default.
- W2044923404 cites W2043251220 @default.
- W2044923404 cites W2049466768 @default.
- W2044923404 cites W2054825874 @default.
- W2044923404 cites W2067220959 @default.
- W2044923404 cites W2078958410 @default.
- W2044923404 cites W2079914602 @default.
- W2044923404 cites W2080134430 @default.
- W2044923404 cites W2081042184 @default.
- W2044923404 cites W2082770888 @default.
- W2044923404 cites W2090150963 @default.
- W2044923404 cites W2092815169 @default.
- W2044923404 cites W2095645474 @default.
- W2044923404 cites W2096338046 @default.
- W2044923404 cites W2113056926 @default.
- W2044923404 cites W2119733059 @default.
- W2044923404 cites W2157630674 @default.
- W2044923404 cites W2157970175 @default.
- W2044923404 cites W2160971502 @default.
- W2044923404 cites W2165444670 @default.
- W2044923404 cites W2176097581 @default.
- W2044923404 cites W2177622286 @default.
- W2044923404 cites W2314039312 @default.
- W2044923404 cites W2315134956 @default.
- W2044923404 cites W2953049687 @default.
- W2044923404 doi "https://doi.org/10.1016/j.ejmech.2011.04.054" @default.
- W2044923404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21571403" @default.
- W2044923404 hasPublicationYear "2011" @default.
- W2044923404 type Work @default.
- W2044923404 sameAs 2044923404 @default.
- W2044923404 citedByCount "104" @default.
- W2044923404 countsByYear W20449234042012 @default.
- W2044923404 countsByYear W20449234042013 @default.
- W2044923404 countsByYear W20449234042014 @default.
- W2044923404 countsByYear W20449234042015 @default.
- W2044923404 countsByYear W20449234042016 @default.
- W2044923404 countsByYear W20449234042017 @default.
- W2044923404 countsByYear W20449234042018 @default.
- W2044923404 countsByYear W20449234042019 @default.
- W2044923404 countsByYear W20449234042020 @default.
- W2044923404 countsByYear W20449234042021 @default.
- W2044923404 countsByYear W20449234042022 @default.
- W2044923404 countsByYear W20449234042023 @default.
- W2044923404 crossrefType "journal-article" @default.
- W2044923404 hasAuthorship W2044923404A5011301639 @default.
- W2044923404 hasAuthorship W2044923404A5015045226 @default.
- W2044923404 hasAuthorship W2044923404A5063979460 @default.
- W2044923404 hasAuthorship W2044923404A5064844460 @default.
- W2044923404 hasAuthorship W2044923404A5068988240 @default.
- W2044923404 hasAuthorship W2044923404A5076267766 @default.
- W2044923404 hasAuthorship W2044923404A5080650553 @default.
- W2044923404 hasConcept C109316439 @default.
- W2044923404 hasConcept C136764020 @default.
- W2044923404 hasConcept C154317977 @default.
- W2044923404 hasConcept C178790620 @default.
- W2044923404 hasConcept C179464577 @default.
- W2044923404 hasConcept C185592680 @default.
- W2044923404 hasConcept C202751555 @default.
- W2044923404 hasConcept C203014093 @default.
- W2044923404 hasConcept C2776090121 @default.
- W2044923404 hasConcept C2776120743 @default.
- W2044923404 hasConcept C2776555147 @default.
- W2044923404 hasConcept C2777752497 @default.
- W2044923404 hasConcept C2778689377 @default.
- W2044923404 hasConcept C2779680806 @default.
- W2044923404 hasConcept C2781092759 @default.
- W2044923404 hasConcept C2781257258 @default.
- W2044923404 hasConcept C2781417161 @default.
- W2044923404 hasConcept C41008148 @default.
- W2044923404 hasConcept C54355233 @default.
- W2044923404 hasConcept C553756173 @default.
- W2044923404 hasConcept C55493867 @default.
- W2044923404 hasConcept C71240020 @default.
- W2044923404 hasConcept C71928629 @default.
- W2044923404 hasConcept C81885089 @default.