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- W2044943876 abstract "Natural α-noscapine, a known antitussive drug, is also now known to possess weak anticancer efficacy with relatively safe toxicity profile. In this study, we report synthesis and evaluation of novel biaryl type α-noscapine congeners designed by adding aryl unit to the tetrahydroisoquinoline part of natural α-noscapine core. Palladium catalyzed Suzuki cross coupling of 9-bromo α-noscapine with aryl boronic acids was employed using mild and inexpensive reagents to attain desired noscapinoids 5a-g in excellent yields. Screening anti-proliferative activity for new noscapinoids 5b-g, on human cancer cell lines resulted three compounds 5b, 5d and 5f as potent analogues, active against human breast epithelial (MCF-7), human cervix cancer (HeLa) and human lung adenocarcinoma epithelial (A549) cell lines." @default.
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- W2044943876 date "2014-12-01" @default.
- W2044943876 modified "2023-10-14" @default.
- W2044943876 title "Synthesis and biological evaluation of novel biaryl type α-noscapine congeners" @default.
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- W2044943876 doi "https://doi.org/10.1016/j.bmcl.2014.10.046" @default.
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