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- W2044954377 endingPage "889" @default.
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- W2044954377 abstract "Proteins participating in immunological signaling have emerged as important targets for controlling the immune response. A multitude of receptor–ligand pairs that regulate signaling pathways of the immune response have been identified. In the complex milieu of immune signaling, therapeutic agents targeting mediators of cellular signaling often either activate an inflammatory immune response or induce tolerance. This review is primarily focused on therapeutics that inhibit the inflammatory immune response by targeting membrane-bound proteins regulating costimulation or mediating immune-cell adhesion. Many of these signals participate in larger, organized structures such as the immunological synapse. Receptor clustering and arrangement into organized structures is also reviewed and emerging trends implicating a potential role for multivalent therapeutics is posited." @default.
- W2044954377 created "2016-06-24" @default.
- W2044954377 creator A5003956897 @default.
- W2044954377 creator A5026304982 @default.
- W2044954377 creator A5050552912 @default.
- W2044954377 creator A5085297918 @default.
- W2044954377 date "2011-07-01" @default.
- W2044954377 modified "2023-10-02" @default.
- W2044954377 title "Autoimmune therapies targeting costimulation and emerging trends in multivalent therapeutics" @default.
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