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• W2044961370 abstract "The EtOAc extract from the leaves of Piper carniconnectivum C. DC. was subjected to chromatographic separation to afford two non-aromatic B-ring flavanone compounds: 5-hydroxy-2-(1′-hydroxy-4′-oxo-cyclohex-2′-en-1′-yl)-6,7-dimethoxy-2,3-dihydro-4H-chromen-4-one (1) and 5-hydroxy-2-(1′,2′-dihydroxy-4′-oxo-cyclohexyl)-6,7-dimethoxy-2,3-dihydro-4H-chromen-4-one (2). The absolute configuration of (+)-1 was unambiguously determined as 2S,1′R by electronic circular dichroism (ECD) spectroscopy and comparison to simulated spectra that were calculated using time-dependent density functional theory (TDDFT). This methodology allowed the assignment of the absolute configuration of (+)-2 also as 2S,1′R, except for the stereogenic center at C-2′, which was assigned as R because of the evidence drawn from high resolution NMR experiments. The cytotoxic activity of both compounds and 3 (hydrogenated B-ring derivative of 1) was evaluated on twelve human leukemia cell lines, and the IC50 values (<10 μM) indicated the activity of 1 against seven cell lines." @default.
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• W2044961370 date "2014-01-01" @default.
• W2044961370 modified "2023-10-01" @default.
• W2044961370 title "Cytotoxic non-aromatic B-ring flavanones from Piper carniconnectivum C. DC." @default.
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• W2044961370 doi "https://doi.org/10.1016/j.phytochem.2013.10.012" @default.
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• W2044961370 hasPublicationYear "2014" @default.
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