Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044962013> ?p ?o ?g. }
- W2044962013 endingPage "438" @default.
- W2044962013 startingPage "433" @default.
- W2044962013 abstract "Chronic anthracycline administration to rabbits causes impairment of cardiac contractility and decreased gene expression of the calcium-induced calcium release channel of sarcoplasmic reticulum (SR), the ryanodine receptor (RYR2). The C-13 hydroxy metabolite (doxorubicinol), formed in the heart, has been hypothesized to contribute to anthracycline cardiotoxicity. C-13 deoxydoxorubicin is an analog unable to form the C-13 hydroxy metabolite. Therefore, doxorubicin, C-13 deoxydoxorubicin, or saline was administered to rabbits (1 mg/kg iv twice weekly for 8 weeks). Left ventricular fractional shortening (LVFS) was decreased by chronic treatment with doxorubicin (28 ± 2%; P < 0.05), but not C-13 deoxydoxorubicin (33 ± 2%) compared to age-matched pair-fed controls. Doxorubicin, but not C-13 deoxydoxorubicin, caused a significant reduction (P < 0.02) in the ratio of RYR2/Ca-Mg ATPase (SERCA2) mRNA levels (0.57 ± 0.1 vs 1.22 ± 0.2, respectively) in the left ventricle. This suggests that doxorubicinol may contribute to the downregulation of cardiac RYR2 expression in chronic doxorubicin cardiotoxicity." @default.
- W2044962013 created "2016-06-24" @default.
- W2044962013 creator A5000355123 @default.
- W2044962013 creator A5001565048 @default.
- W2044962013 creator A5002348205 @default.
- W2044962013 creator A5017071848 @default.
- W2044962013 creator A5039679313 @default.
- W2044962013 creator A5075332653 @default.
- W2044962013 creator A5083198774 @default.
- W2044962013 date "2002-03-01" @default.
- W2044962013 modified "2023-09-30" @default.
- W2044962013 title "Doxorubicin and C-13 Deoxydoxorubicin Effects on Ryanodine Receptor Gene Expression" @default.
- W2044962013 cites W1557449322 @default.
- W2044962013 cites W1626344016 @default.
- W2044962013 cites W1791262955 @default.
- W2044962013 cites W1967995621 @default.
- W2044962013 cites W1969182421 @default.
- W2044962013 cites W1976347407 @default.
- W2044962013 cites W1977029462 @default.
- W2044962013 cites W1982178587 @default.
- W2044962013 cites W1992738774 @default.
- W2044962013 cites W1996423501 @default.
- W2044962013 cites W1997866681 @default.
- W2044962013 cites W1998838410 @default.
- W2044962013 cites W2006741122 @default.
- W2044962013 cites W2009706695 @default.
- W2044962013 cites W2023470676 @default.
- W2044962013 cites W2034113803 @default.
- W2044962013 cites W2056359548 @default.
- W2044962013 cites W2058337944 @default.
- W2044962013 cites W2066712429 @default.
- W2044962013 cites W2073912429 @default.
- W2044962013 cites W2086309499 @default.
- W2044962013 cites W2094516152 @default.
- W2044962013 cites W2119492932 @default.
- W2044962013 cites W2119544587 @default.
- W2044962013 cites W2146838679 @default.
- W2044962013 cites W2158325136 @default.
- W2044962013 cites W2163331945 @default.
- W2044962013 cites W2261736960 @default.
- W2044962013 doi "https://doi.org/10.1006/bbrc.2002.6380" @default.
- W2044962013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11855807" @default.
- W2044962013 hasPublicationYear "2002" @default.
- W2044962013 type Work @default.
- W2044962013 sameAs 2044962013 @default.
- W2044962013 citedByCount "39" @default.
- W2044962013 countsByYear W20449620132012 @default.
- W2044962013 countsByYear W20449620132013 @default.
- W2044962013 countsByYear W20449620132014 @default.
- W2044962013 countsByYear W20449620132016 @default.
- W2044962013 countsByYear W20449620132018 @default.
- W2044962013 countsByYear W20449620132019 @default.
- W2044962013 countsByYear W20449620132020 @default.
- W2044962013 countsByYear W20449620132021 @default.
- W2044962013 countsByYear W20449620132022 @default.
- W2044962013 countsByYear W20449620132023 @default.
- W2044962013 crossrefType "journal-article" @default.
- W2044962013 hasAuthorship W2044962013A5000355123 @default.
- W2044962013 hasAuthorship W2044962013A5001565048 @default.
- W2044962013 hasAuthorship W2044962013A5002348205 @default.
- W2044962013 hasAuthorship W2044962013A5017071848 @default.
- W2044962013 hasAuthorship W2044962013A5039679313 @default.
- W2044962013 hasAuthorship W2044962013A5075332653 @default.
- W2044962013 hasAuthorship W2044962013A5083198774 @default.
- W2044962013 hasConcept C113217602 @default.
- W2044962013 hasConcept C121608353 @default.
- W2044962013 hasConcept C126322002 @default.
- W2044962013 hasConcept C134018914 @default.
- W2044962013 hasConcept C158617107 @default.
- W2044962013 hasConcept C185592680 @default.
- W2044962013 hasConcept C190712762 @default.
- W2044962013 hasConcept C2775953344 @default.
- W2044962013 hasConcept C2776694085 @default.
- W2044962013 hasConcept C2776802502 @default.
- W2044962013 hasConcept C2777477808 @default.
- W2044962013 hasConcept C2778233292 @default.
- W2044962013 hasConcept C2778921608 @default.
- W2044962013 hasConcept C2781303535 @default.
- W2044962013 hasConcept C29730261 @default.
- W2044962013 hasConcept C39133596 @default.
- W2044962013 hasConcept C519063684 @default.
- W2044962013 hasConcept C530470458 @default.
- W2044962013 hasConcept C55493867 @default.
- W2044962013 hasConcept C71924100 @default.
- W2044962013 hasConcept C98274493 @default.
- W2044962013 hasConceptScore W2044962013C113217602 @default.
- W2044962013 hasConceptScore W2044962013C121608353 @default.
- W2044962013 hasConceptScore W2044962013C126322002 @default.
- W2044962013 hasConceptScore W2044962013C134018914 @default.
- W2044962013 hasConceptScore W2044962013C158617107 @default.
- W2044962013 hasConceptScore W2044962013C185592680 @default.
- W2044962013 hasConceptScore W2044962013C190712762 @default.
- W2044962013 hasConceptScore W2044962013C2775953344 @default.
- W2044962013 hasConceptScore W2044962013C2776694085 @default.
- W2044962013 hasConceptScore W2044962013C2776802502 @default.
- W2044962013 hasConceptScore W2044962013C2777477808 @default.
- W2044962013 hasConceptScore W2044962013C2778233292 @default.
- W2044962013 hasConceptScore W2044962013C2778921608 @default.