Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044965692> ?p ?o ?g. }
- W2044965692 endingPage "77" @default.
- W2044965692 startingPage "65" @default.
- W2044965692 abstract "Tryparedoxins (TXNs) are multipurpose oxidoreductases from trypanosomatids that transfer reducing equivalents from trypanothione to various thiol proteins. In Trypanosoma cruzi, two genes coding for TXN-like proteins have been identified: TXNI, previously characterized as a cytoplasmic protein, and TXNII, a putative tail-anchored membrane protein. In this work, we performed a comparative functional characterization of T. cruzi TXNs. Particularly, we cloned the gene region coding for the soluble version of TXNII for its heterologous expression. The truncated recombinant protein (without its 22 C-terminal transmembrane amino acids) showed TXN activity. It was also able to transfer reducing equivalents from trypanothione, glutathione, or dihydrolipoamide to various acceptors, including methionine sulfoxide reductases and peroxiredoxins. The results support the occurrence and functionality of a second tryparedoxin, which appears as a new component in the redox scenario for T. cruzi." @default.
- W2044965692 created "2016-06-24" @default.
- W2044965692 creator A5027543036 @default.
- W2044965692 creator A5040112530 @default.
- W2044965692 creator A5040975103 @default.
- W2044965692 creator A5056884371 @default.
- W2044965692 creator A5073164998 @default.
- W2044965692 creator A5076594950 @default.
- W2044965692 creator A5088172747 @default.
- W2044965692 date "2013-10-01" @default.
- W2044965692 modified "2023-10-12" @default.
- W2044965692 title "Redox metabolism in Trypanosoma cruzi: Functional characterization of tryparedoxins revisited" @default.
- W2044965692 cites W156089625 @default.
- W2044965692 cites W1967618518 @default.
- W2044965692 cites W1970732978 @default.
- W2044965692 cites W1972530911 @default.
- W2044965692 cites W1973554224 @default.
- W2044965692 cites W1977273560 @default.
- W2044965692 cites W1987365521 @default.
- W2044965692 cites W1988565813 @default.
- W2044965692 cites W1992669214 @default.
- W2044965692 cites W1992801869 @default.
- W2044965692 cites W1996609836 @default.
- W2044965692 cites W2001624459 @default.
- W2044965692 cites W2002649836 @default.
- W2044965692 cites W2016149043 @default.
- W2044965692 cites W2016498245 @default.
- W2044965692 cites W2016750648 @default.
- W2044965692 cites W2018506866 @default.
- W2044965692 cites W2020421560 @default.
- W2044965692 cites W2021822101 @default.
- W2044965692 cites W2023772678 @default.
- W2044965692 cites W2024981582 @default.
- W2044965692 cites W2028097028 @default.
- W2044965692 cites W2029868188 @default.
- W2044965692 cites W2035523275 @default.
- W2044965692 cites W2045244635 @default.
- W2044965692 cites W2046013583 @default.
- W2044965692 cites W2046784759 @default.
- W2044965692 cites W2052802966 @default.
- W2044965692 cites W2055181353 @default.
- W2044965692 cites W205714514 @default.
- W2044965692 cites W2057714154 @default.
- W2044965692 cites W2060040352 @default.
- W2044965692 cites W2063078080 @default.
- W2044965692 cites W2063576996 @default.
- W2044965692 cites W2064153475 @default.
- W2044965692 cites W2069079356 @default.
- W2044965692 cites W2072873811 @default.
- W2044965692 cites W2073803104 @default.
- W2044965692 cites W2074929773 @default.
- W2044965692 cites W2081297467 @default.
- W2044965692 cites W2082704763 @default.
- W2044965692 cites W2084505046 @default.
- W2044965692 cites W2087174618 @default.
- W2044965692 cites W2090150963 @default.
- W2044965692 cites W2091660245 @default.
- W2044965692 cites W2094688958 @default.
- W2044965692 cites W2094746785 @default.
- W2044965692 cites W2098857744 @default.
- W2044965692 cites W2100837269 @default.
- W2044965692 cites W2109683193 @default.
- W2044965692 cites W2118502069 @default.
- W2044965692 cites W2129576311 @default.
- W2044965692 cites W2132878122 @default.
- W2044965692 cites W2142254608 @default.
- W2044965692 cites W2157504129 @default.
- W2044965692 cites W2204173622 @default.
- W2044965692 cites W290744757 @default.
- W2044965692 cites W4293247451 @default.
- W2044965692 cites W66633716 @default.
- W2044965692 cites W92910993 @default.
- W2044965692 cites W2007955695 @default.
- W2044965692 doi "https://doi.org/10.1016/j.freeradbiomed.2013.04.036" @default.
- W2044965692 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23665397" @default.
- W2044965692 hasPublicationYear "2013" @default.
- W2044965692 type Work @default.
- W2044965692 sameAs 2044965692 @default.
- W2044965692 citedByCount "36" @default.
- W2044965692 countsByYear W20449656922014 @default.
- W2044965692 countsByYear W20449656922015 @default.
- W2044965692 countsByYear W20449656922016 @default.
- W2044965692 countsByYear W20449656922017 @default.
- W2044965692 countsByYear W20449656922018 @default.
- W2044965692 countsByYear W20449656922019 @default.
- W2044965692 countsByYear W20449656922020 @default.
- W2044965692 countsByYear W20449656922021 @default.
- W2044965692 countsByYear W20449656922022 @default.
- W2044965692 countsByYear W20449656922023 @default.
- W2044965692 crossrefType "journal-article" @default.
- W2044965692 hasAuthorship W2044965692A5027543036 @default.
- W2044965692 hasAuthorship W2044965692A5040112530 @default.
- W2044965692 hasAuthorship W2044965692A5040975103 @default.
- W2044965692 hasAuthorship W2044965692A5056884371 @default.
- W2044965692 hasAuthorship W2044965692A5073164998 @default.
- W2044965692 hasAuthorship W2044965692A5076594950 @default.
- W2044965692 hasAuthorship W2044965692A5088172747 @default.
- W2044965692 hasBestOaLocation W20449656922 @default.