FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044968229> ?p ?o ?g. }

• W2044968229 endingPage "63" @default.
• W2044968229 startingPage "52" @default.
• W2044968229 abstract "Dichloroacetate (2 mm) stimulated the conversion of [1-14C]lactate to glucose in hepatocytes from fed rats. In hepatocytes from rats starved for 24 h, where the mitochondrial NADHNAD+ ratio is elevated, dichloroacetate inhibited the conversion of [1-14C]lactate to glucose. Dichloroacetate stimulated 14CO2 production from [1-14C]lactate in both cases. It also completely activated pyruvate dehydrogenase and increased flux through the enzyme. The addition of β-hydroxybutyrate, which elevates the intramitochondrial NADHNAD+ ratio, changed the metabolism of [1-14C]lactate in hepatocytes from fed rats to a pattern similar to that seen in hepatocytes from starved rats. Thus, the effect of dichloroacetate on labeled glucose synthesis from lactate appears to depend on the mitochondrial oxidation-reduction state of the hepatocytes. Glucagon (10 nm) stimulated labeled glucose synthesis from lactate or alanine in hepatocytes from both fed and starved rats and in the absence or presence of dichloroacetate. The hormone had no effect on pyruvate dehydrogenase activity whether or not the enzyme had been activated by dichloroacetate. Thus, it appears that pyruvate dehydrogenase is not involved in the hormonal regulation of gluconeogenesis. Glucagon inhibited the incorporation of 10 mm [1-14C]pyruvate into glucose in hepatocytes from starved rats. This inhibition has been attributed to an inhibition of pyruvate dehydrogenase by the hormone (Zahlten et al., 1973, Proc. Nat. Acad. Sci. USA70, 3213–3218). However, dichloroacetate did not prevent the inhibition of glucose synthesis. Nor did glucagon alter the activity of pyruvate dehydrogenase in homogenates of cells that had been incubated with 10 mm pyruvate in the absence or presence of dichloroacetate. Thus, the inhibition by glucagon of pyruvate gluconeogenesis does not appear to be due to an inhibition of pyruvate dehydrogenase." @default.
• W2044968229 created "2016-06-24" @default.
• W2044968229 creator A5035876596 @default.
• W2044968229 creator A5078482941 @default.
• W2044968229 date "1977-07-01" @default.
• W2044968229 modified "2023-10-18" @default.
• W2044968229 title "Effect of dichloroacetate and glucagon on the incorporation of labeled substrates into glucose and on pyruvate dehydrogenase in hepatocytes from fed and starved rats" @default.
• W2044968229 cites W1493348989 @default.
• W2044968229 cites W150236024 @default.
• W2044968229 cites W1524136845 @default.
• W2044968229 cites W1527612610 @default.
• W2044968229 cites W1537421998 @default.
• W2044968229 cites W1541460729 @default.
• W2044968229 cites W1544747395 @default.
• W2044968229 cites W1556860936 @default.
• W2044968229 cites W1559132754 @default.
• W2044968229 cites W1588593248 @default.
• W2044968229 cites W1757455318 @default.
• W2044968229 cites W1759931938 @default.
• W2044968229 cites W1845254999 @default.
• W2044968229 cites W195471417 @default.
• W2044968229 cites W1965664048 @default.
• W2044968229 cites W1977043167 @default.
• W2044968229 cites W1991772978 @default.
• W2044968229 cites W2002633984 @default.
• W2044968229 cites W2008952536 @default.
• W2044968229 cites W2022259755 @default.
• W2044968229 cites W2029084148 @default.
• W2044968229 cites W2033930625 @default.
• W2044968229 cites W2036224084 @default.
• W2044968229 cites W2067455192 @default.
• W2044968229 cites W2072482644 @default.
• W2044968229 cites W2082089322 @default.
• W2044968229 cites W2091217442 @default.
• W2044968229 cites W2102064386 @default.
• W2044968229 cites W2133422577 @default.
• W2044968229 cites W2344368547 @default.
• W2044968229 cites W84564858 @default.
• W2044968229 doi "https://doi.org/10.1016/0003-9861(77)90282-x" @default.
• W2044968229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/883838" @default.
• W2044968229 hasPublicationYear "1977" @default.
• W2044968229 type Work @default.
• W2044968229 sameAs 2044968229 @default.
• W2044968229 citedByCount "44" @default.
• W2044968229 crossrefType "journal-article" @default.
• W2044968229 hasAuthorship W2044968229A5035876596 @default.
• W2044968229 hasAuthorship W2044968229A5078482941 @default.
• W2044968229 hasConcept C101972281 @default.
• W2044968229 hasConcept C126322002 @default.
• W2044968229 hasConcept C134018914 @default.
• W2044968229 hasConcept C140137476 @default.
• W2044968229 hasConcept C181199279 @default.
• W2044968229 hasConcept C185592680 @default.
• W2044968229 hasConcept C190098323 @default.
• W2044968229 hasConcept C20904676 @default.
• W2044968229 hasConcept C2776317432 @default.
• W2044968229 hasConcept C2777318727 @default.
• W2044968229 hasConcept C2778563252 @default.
• W2044968229 hasConcept C55493867 @default.
• W2044968229 hasConcept C62231903 @default.
• W2044968229 hasConcept C71315377 @default.
• W2044968229 hasConcept C71924100 @default.
• W2044968229 hasConcept C86803240 @default.
• W2044968229 hasConcept C88099638 @default.
• W2044968229 hasConcept C9506865 @default.
• W2044968229 hasConceptScore W2044968229C101972281 @default.
• W2044968229 hasConceptScore W2044968229C126322002 @default.
• W2044968229 hasConceptScore W2044968229C134018914 @default.
• W2044968229 hasConceptScore W2044968229C140137476 @default.
• W2044968229 hasConceptScore W2044968229C181199279 @default.
• W2044968229 hasConceptScore W2044968229C185592680 @default.
• W2044968229 hasConceptScore W2044968229C190098323 @default.
• W2044968229 hasConceptScore W2044968229C20904676 @default.
• W2044968229 hasConceptScore W2044968229C2776317432 @default.
• W2044968229 hasConceptScore W2044968229C2777318727 @default.
• W2044968229 hasConceptScore W2044968229C2778563252 @default.
• W2044968229 hasConceptScore W2044968229C55493867 @default.
• W2044968229 hasConceptScore W2044968229C62231903 @default.
• W2044968229 hasConceptScore W2044968229C71315377 @default.
• W2044968229 hasConceptScore W2044968229C71924100 @default.
• W2044968229 hasConceptScore W2044968229C86803240 @default.
• W2044968229 hasConceptScore W2044968229C88099638 @default.
• W2044968229 hasConceptScore W2044968229C9506865 @default.
• W2044968229 hasIssue "1" @default.
• W2044968229 hasLocation W20449682291 @default.
• W2044968229 hasLocation W20449682292 @default.
• W2044968229 hasOpenAccess W2044968229 @default.
• W2044968229 hasPrimaryLocation W20449682291 @default.
• W2044968229 hasRelatedWork W1550584399 @default.
• W2044968229 hasRelatedWork W186376918 @default.
• W2044968229 hasRelatedWork W2002287256 @default.
• W2044968229 hasRelatedWork W2057778506 @default.
• W2044968229 hasRelatedWork W2094654811 @default.
• W2044968229 hasRelatedWork W227457034 @default.
• W2044968229 hasRelatedWork W2396817814 @default.
• W2044968229 hasRelatedWork W2415728211 @default.
• W2044968229 hasRelatedWork W2489850256 @default.
• W2044968229 hasRelatedWork W57588594 @default.

• next