FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044972611> ?p ?o ?g. }

• W2044972611 endingPage "297" @default.
• W2044972611 startingPage "288" @default.
• W2044972611 abstract "This placebo-controlled, double-blind, longitudinal crossover study compares the efficacy of disopyramide and ethmozine, a new investigational drug, in suppressing frequent (40 or more per hour) ventricular premature depolarizations (VPDs) in 27 patients completing a 37 day protocol. Although both drugs significantly reduced VPDs relative to placebo, ethmozine was a superior antiarrhythmic drug in ach9eving near-total abolition of VPDs (30% of patients), which was never observed during disopyramide dosing (p less than .05). At the 80% VPD reduction level, ethmozine was effective in 56% of all patients compared with an effectiveness in only 22% of patients during disopyramide therapy (p less than .05). The mean peak plasma level of ethmozine was 0.66 +/- 0.8 micrograms/ml, which significantly fell to a trough level of 0.1 +/- 0.08 micrograms/ml (p less than .001). Mean peak and trough plasma levels of disopyramide exhibited less fluctuation (2.6 +/- 0.9 micrograms/ml vs 2.2 +/- 0.9 micrograms/ml). Ethmozine had no effect on the QT interval, whereas disopyramide prolonged it significantly. Importantly, while disopyramide produced serious side effects in 30% of patients, ethmozine was well tolerated with no statistically significant side effects compared with placebo." @default.
• W2044972611 created "2016-06-24" @default.
• W2044972611 creator A5005707656 @default.
• W2044972611 creator A5006688566 @default.
• W2044972611 creator A5014825902 @default.
• W2044972611 creator A5016061416 @default.
• W2044972611 creator A5031026816 @default.
• W2044972611 creator A5034261959 @default.
• W2044972611 creator A5055187073 @default.
• W2044972611 creator A5056111953 @default.
• W2044972611 creator A5074247327 @default.
• W2044972611 creator A5083179513 @default.
• W2044972611 date "1984-02-01" @default.
• W2044972611 modified "2023-09-26" @default.
• W2044972611 title "Comparative effect of disopyramide and ethmozine in suppressing complex ventricular arrhythmias by use of a double-blind, placebo-controlled, longitudinal crossover design." @default.
• W2044972611 cites W1966774249 @default.
• W2044972611 cites W1978447069 @default.
• W2044972611 cites W1980270370 @default.
• W2044972611 cites W1984595407 @default.
• W2044972611 cites W1991120591 @default.
• W2044972611 cites W1993446039 @default.
• W2044972611 cites W1993847838 @default.
• W2044972611 cites W1998769682 @default.
• W2044972611 cites W1999710905 @default.
• W2044972611 cites W2002753439 @default.
• W2044972611 cites W2005829217 @default.
• W2044972611 cites W2006565016 @default.
• W2044972611 cites W2013600236 @default.
• W2044972611 cites W2014562798 @default.
• W2044972611 cites W2015169899 @default.
• W2044972611 cites W2021960756 @default.
• W2044972611 cites W2024190777 @default.
• W2044972611 cites W2024907928 @default.
• W2044972611 cites W2030122380 @default.
• W2044972611 cites W2038203329 @default.
• W2044972611 cites W2044729302 @default.
• W2044972611 cites W2051488169 @default.
• W2044972611 cites W2051514541 @default.
• W2044972611 cites W2058204306 @default.
• W2044972611 cites W2074170113 @default.
• W2044972611 cites W2075604306 @default.
• W2044972611 cites W2087410496 @default.
• W2044972611 cites W2093823779 @default.
• W2044972611 cites W2126434529 @default.
• W2044972611 cites W2166484344 @default.
• W2044972611 cites W2340830615 @default.
• W2044972611 cites W2418599448 @default.
• W2044972611 cites W2471446929 @default.
• W2044972611 cites W2973517509 @default.
• W2044972611 cites W4230271242 @default.
• W2044972611 cites W4239111797 @default.
• W2044972611 cites W4244341064 @default.
• W2044972611 doi "https://doi.org/10.1161/01.cir.69.2.288" @default.
• W2044972611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6360413" @default.
• W2044972611 hasPublicationYear "1984" @default.
• W2044972611 type Work @default.
• W2044972611 sameAs 2044972611 @default.
• W2044972611 citedByCount "51" @default.
• W2044972611 countsByYear W20449726112018 @default.
• W2044972611 countsByYear W20449726112022 @default.
• W2044972611 crossrefType "journal-article" @default.
• W2044972611 hasAuthorship W2044972611A5005707656 @default.
• W2044972611 hasAuthorship W2044972611A5006688566 @default.
• W2044972611 hasAuthorship W2044972611A5014825902 @default.
• W2044972611 hasAuthorship W2044972611A5016061416 @default.
• W2044972611 hasAuthorship W2044972611A5031026816 @default.
• W2044972611 hasAuthorship W2044972611A5034261959 @default.
• W2044972611 hasAuthorship W2044972611A5055187073 @default.
• W2044972611 hasAuthorship W2044972611A5056111953 @default.
• W2044972611 hasAuthorship W2044972611A5074247327 @default.
• W2044972611 hasAuthorship W2044972611A5083179513 @default.
• W2044972611 hasBestOaLocation W20449726111 @default.
• W2044972611 hasConcept C126322002 @default.
• W2044972611 hasConcept C142724271 @default.
• W2044972611 hasConcept C164705383 @default.
• W2044972611 hasConcept C204787440 @default.
• W2044972611 hasConcept C27081682 @default.
• W2044972611 hasConcept C2777288759 @default.
• W2044972611 hasConcept C2779831137 @default.
• W2044972611 hasConcept C42219234 @default.
• W2044972611 hasConcept C71924100 @default.
• W2044972611 hasConcept C87813604 @default.
• W2044972611 hasConcept C98274493 @default.
• W2044972611 hasConceptScore W2044972611C126322002 @default.
• W2044972611 hasConceptScore W2044972611C142724271 @default.
• W2044972611 hasConceptScore W2044972611C164705383 @default.
• W2044972611 hasConceptScore W2044972611C204787440 @default.
• W2044972611 hasConceptScore W2044972611C27081682 @default.
• W2044972611 hasConceptScore W2044972611C2777288759 @default.
• W2044972611 hasConceptScore W2044972611C2779831137 @default.
• W2044972611 hasConceptScore W2044972611C42219234 @default.
• W2044972611 hasConceptScore W2044972611C71924100 @default.
• W2044972611 hasConceptScore W2044972611C87813604 @default.
• W2044972611 hasConceptScore W2044972611C98274493 @default.
• W2044972611 hasIssue "2" @default.
• W2044972611 hasLocation W20449726111 @default.
• W2044972611 hasLocation W20449726112 @default.
• W2044972611 hasOpenAccess W2044972611 @default.

• next