Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044973682> ?p ?o ?g. }
- W2044973682 endingPage "611" @default.
- W2044973682 startingPage "605" @default.
- W2044973682 abstract "Dopaminergic D1/D5-receptor-mediated processes are important for certain forms of memory as well as for a cellular model of memory, hippocampal long-term potentiation (LTP) in the CA1 region of the hippocampus. D1/D5-receptor function is required for the induction of the protein synthesis-dependent maintenance of CA1-LTP (L-LTP) through activation of the cAMP/PKA-pathway. In earlier studies we had reported a synergistic interaction of D1/D5-receptor function and N-methyl-D-aspartate (NMDA)-receptors for L-LTP. Furthermore, we have found the requirement of the atypical protein kinase C isoform, protein kinase Mζ (PKMζ) for conventional electrically induced L-LTP, in which PKMζ has been identified as a LTP-specific plasticity-related protein (PRP) in apical CA1-dendrites. Here, we investigated whether the dopaminergic pathway activates PKMζ. We found that application of dopamine (DA) evokes a protein synthesis-dependent LTP that requires synergistic NMDA-receptor activation and protein synthesis in apical CA1-dendrites. We identified PKMζ as a DA-induced PRP, which exerted its action at activated synaptic inputs by processes of synaptic tagging." @default.
- W2044973682 created "2016-06-24" @default.
- W2044973682 creator A5036644252 @default.
- W2044973682 creator A5058252786 @default.
- W2044973682 creator A5071613887 @default.
- W2044973682 creator A5086067249 @default.
- W2044973682 date "2010-11-17" @default.
- W2044973682 modified "2023-09-26" @default.
- W2044973682 title "Protein kinase Mζ is essential for the induction and maintenance of dopamine-induced long-term potentiation in apical CA1 dendrites" @default.
- W2044973682 cites W1571281589 @default.
- W2044973682 cites W1590525559 @default.
- W2044973682 cites W1868297237 @default.
- W2044973682 cites W1897237761 @default.
- W2044973682 cites W1964310366 @default.
- W2044973682 cites W1969507049 @default.
- W2044973682 cites W1973167605 @default.
- W2044973682 cites W1975705681 @default.
- W2044973682 cites W1992084781 @default.
- W2044973682 cites W1995001752 @default.
- W2044973682 cites W2002927748 @default.
- W2044973682 cites W2003237927 @default.
- W2044973682 cites W2005744880 @default.
- W2044973682 cites W2016118632 @default.
- W2044973682 cites W2017056195 @default.
- W2044973682 cites W2018662966 @default.
- W2044973682 cites W2020440721 @default.
- W2044973682 cites W2020969390 @default.
- W2044973682 cites W2021485981 @default.
- W2044973682 cites W2031104034 @default.
- W2044973682 cites W2034723011 @default.
- W2044973682 cites W2037457092 @default.
- W2044973682 cites W2041251386 @default.
- W2044973682 cites W2050490808 @default.
- W2044973682 cites W2051473177 @default.
- W2044973682 cites W2051716212 @default.
- W2044973682 cites W2058053468 @default.
- W2044973682 cites W2063055145 @default.
- W2044973682 cites W2069469260 @default.
- W2044973682 cites W2073370366 @default.
- W2044973682 cites W2084983336 @default.
- W2044973682 cites W2086045560 @default.
- W2044973682 cites W2086789852 @default.
- W2044973682 cites W2089701555 @default.
- W2044973682 cites W2095512479 @default.
- W2044973682 cites W2096081604 @default.
- W2044973682 cites W2097872145 @default.
- W2044973682 cites W2121007598 @default.
- W2044973682 cites W2164461730 @default.
- W2044973682 cites W2168456060 @default.
- W2044973682 cites W2313176671 @default.
- W2044973682 cites W828903267 @default.
- W2044973682 doi "https://doi.org/10.1101/lm.1991910" @default.
- W2044973682 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2998336" @default.
- W2044973682 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21084457" @default.
- W2044973682 hasPublicationYear "2010" @default.
- W2044973682 type Work @default.
- W2044973682 sameAs 2044973682 @default.
- W2044973682 citedByCount "33" @default.
- W2044973682 countsByYear W20449736822012 @default.
- W2044973682 countsByYear W20449736822013 @default.
- W2044973682 countsByYear W20449736822014 @default.
- W2044973682 countsByYear W20449736822015 @default.
- W2044973682 countsByYear W20449736822016 @default.
- W2044973682 countsByYear W20449736822017 @default.
- W2044973682 countsByYear W20449736822018 @default.
- W2044973682 countsByYear W20449736822019 @default.
- W2044973682 countsByYear W20449736822020 @default.
- W2044973682 countsByYear W20449736822021 @default.
- W2044973682 countsByYear W20449736822022 @default.
- W2044973682 crossrefType "journal-article" @default.
- W2044973682 hasAuthorship W2044973682A5036644252 @default.
- W2044973682 hasAuthorship W2044973682A5058252786 @default.
- W2044973682 hasAuthorship W2044973682A5071613887 @default.
- W2044973682 hasAuthorship W2044973682A5086067249 @default.
- W2044973682 hasBestOaLocation W20449736821 @default.
- W2044973682 hasConcept C120069818 @default.
- W2044973682 hasConcept C137183658 @default.
- W2044973682 hasConcept C169760540 @default.
- W2044973682 hasConcept C170493617 @default.
- W2044973682 hasConcept C184235292 @default.
- W2044973682 hasConcept C185592680 @default.
- W2044973682 hasConcept C25274449 @default.
- W2044973682 hasConcept C2776328245 @default.
- W2044973682 hasConcept C513476851 @default.
- W2044973682 hasConcept C55493867 @default.
- W2044973682 hasConcept C67018056 @default.
- W2044973682 hasConcept C86803240 @default.
- W2044973682 hasConcept C95444343 @default.
- W2044973682 hasConcept C97029542 @default.
- W2044973682 hasConcept C98229152 @default.
- W2044973682 hasConceptScore W2044973682C120069818 @default.
- W2044973682 hasConceptScore W2044973682C137183658 @default.
- W2044973682 hasConceptScore W2044973682C169760540 @default.
- W2044973682 hasConceptScore W2044973682C170493617 @default.
- W2044973682 hasConceptScore W2044973682C184235292 @default.
- W2044973682 hasConceptScore W2044973682C185592680 @default.
- W2044973682 hasConceptScore W2044973682C25274449 @default.
- W2044973682 hasConceptScore W2044973682C2776328245 @default.