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- W2044976222 abstract "Local injection of cysteamine into rat striatum resulted in a dose-dependent reduction in somatostatin-like immunoreactivity (SLI). The effect was seen at 1 h, and persisted for up to 72 h, but was reversible at 1 week. The maximal depletion of SLI was approximately 50%. Histologic damage was largely confined to the needle tract. Of interest was a depletion of SLI in the contralateral striatum beginning at 3 h and maximal at 72 h. Cysteamine induced depletion of striatal SLI was not accompanied by alterations in dopamine or serotonin metabolism. Cysteamine is a useful pharmacologic tool for local somatostatin depletion." @default.
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- W2044976222 date "1984-08-01" @default.
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- W2044976222 title "Depletion of striatal somatostatin by local cysteamine injection" @default.
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- W2044976222 doi "https://doi.org/10.1016/0006-8993(84)91071-0" @default.
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