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- W2044987789 abstract "We have purified and characterized a glycopeptide from surfaces of brain cortex cells that inhibits cellular protein synthesis in normal but not transformed cells. Data are presented that correlate the ability of C3H fibrosarcoma 1316 cells to avoid the inhibitor's activity with a reduced cellular level of the ganglioside GM1. When 1316 cells were incubated with GM1 under conditions in which the ganglioside is incorporated into the cells, the cells became sensitive to the inhibitor, Similar experiments with ceramide resulted in no change in 1316 sensitivity. In addition, when 1316 cells were incubated with GM1 for 18 h, they apparently metabolized GM1 to simpler gangliosides and lost their sensitivity to the glycopeptide inhibitor." @default.
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- W2044987789 date "1982-07-01" @default.
- W2044987789 modified "2023-10-18" @default.
- W2044987789 title "Ganglioside GM1 sensitizes tumor cells to growth inhibitory glycopeptides" @default.
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- W2044987789 doi "https://doi.org/10.1016/0006-291x(82)91542-x" @default.
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