FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044989255> ?p ?o ?g. }

• W2044989255 endingPage "294" @default.
• W2044989255 startingPage "286" @default.
• W2044989255 abstract "We showed previously that choline administration protects dogs from endotoxin-induced multiple organ injury and platelet dysfunctions. Because sepsis/endotoxemia is associated with alterations in lipid metabolism, we have investigated whether choline or cytidine-5'-diphosphate choline, a choline donor, alters serum lipid responses to endotoxin in dogs and rats. In response to endotoxin, serum concentrations of triglycerides, choline-containing phospholipids, total cholesterol, and high-density lipoprotein cholesterol increased in a dose- and time-related manner. Administration of choline (20 mg/kg i.v. in dogs or 90 mg/kg i.p. in rats) or cytidine-5'-diphosphate choline (70 mg/kg i.v. in dogs) 5 min before and 4 and 8 h after endotoxin blocked or attenuated the increases in serum triglycerides, total cholesterol, and nonesterified fatty acids. Endotoxin-induced elevations in serum phospholipid levels did not change in rats and were enhanced in dogs by choline. In rats, serum lipid response to endotoxin was accompanied by severalfold elevations in serum levels of hepatorenal injury markers; their elevations were also blocked by choline. Pretreatment with hexamethonium blocked choline's effects on serum lipids and hepatorenal injury markers. Pretreatment with atropine blocked endotoxin-induced elevations in serum lipid and hepatorenal injury markers, but failed to alter choline's actions on these parameters. Choline treatment improved survival rate of rats in lethal endotoxin shock. In conclusion, these data show that choline treatment alters serum lipid responses to endotoxin and prevents hepatorenal injury during endotoxemia through a nicotinic acetylcholine receptor-mediated mechanism. Hence, choline and choline-containing compounds may have a therapeutic potential in the treatment of endotoxemia/sepsis." @default.
• W2044989255 created "2016-06-24" @default.
• W2044989255 creator A5021963150 @default.
• W2044989255 creator A5035900283 @default.
• W2044989255 creator A5051699127 @default.
• W2044989255 creator A5054809884 @default.
• W2044989255 date "2009-09-01" @default.
• W2044989255 modified "2023-09-25" @default.
• W2044989255 title "CHOLINE OR CDP-CHOLINE ALTERS SERUM LIPID RESPONSES TO ENDOTOXIN IN DOGS AND RATS: INVOLVEMENT OF THE PERIPHERAL NICOTINIC ACETYLCHOLINE RECEPTORS" @default.
• W2044989255 cites W1500979124 @default.
• W2044989255 cites W1577070562 @default.
• W2044989255 cites W160527081 @default.
• W2044989255 cites W1969117650 @default.
• W2044989255 cites W1973637278 @default.
• W2044989255 cites W1983425121 @default.
• W2044989255 cites W1983844880 @default.
• W2044989255 cites W1987474453 @default.
• W2044989255 cites W1995048467 @default.
• W2044989255 cites W2002797282 @default.
• W2044989255 cites W2011895411 @default.
• W2044989255 cites W2023117694 @default.
• W2044989255 cites W2037128810 @default.
• W2044989255 cites W2040339940 @default.
• W2044989255 cites W2042710688 @default.
• W2044989255 cites W2054598711 @default.
• W2044989255 cites W2055041145 @default.
• W2044989255 cites W2059704497 @default.
• W2044989255 cites W2061089980 @default.
• W2044989255 cites W2062586737 @default.
• W2044989255 cites W2071179731 @default.
• W2044989255 cites W2072753217 @default.
• W2044989255 cites W2073859623 @default.
• W2044989255 cites W2131524835 @default.
• W2044989255 cites W2134215776 @default.
• W2044989255 cites W2147096593 @default.
• W2044989255 cites W2155536294 @default.
• W2044989255 cites W2158796327 @default.
• W2044989255 cites W2164353385 @default.
• W2044989255 cites W2166757392 @default.
• W2044989255 cites W2328008518 @default.
• W2044989255 cites W2329935244 @default.
• W2044989255 doi "https://doi.org/10.1097/shk.0b013e3181971b02" @default.
• W2044989255 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19060783" @default.
• W2044989255 hasPublicationYear "2009" @default.
• W2044989255 type Work @default.
• W2044989255 sameAs 2044989255 @default.
• W2044989255 citedByCount "31" @default.
• W2044989255 countsByYear W20449892552012 @default.
• W2044989255 countsByYear W20449892552013 @default.
• W2044989255 countsByYear W20449892552014 @default.
• W2044989255 countsByYear W20449892552015 @default.
• W2044989255 countsByYear W20449892552016 @default.
• W2044989255 countsByYear W20449892552017 @default.
• W2044989255 countsByYear W20449892552019 @default.
• W2044989255 countsByYear W20449892552020 @default.
• W2044989255 countsByYear W20449892552021 @default.
• W2044989255 countsByYear W20449892552022 @default.
• W2044989255 crossrefType "journal-article" @default.
• W2044989255 hasAuthorship W2044989255A5021963150 @default.
• W2044989255 hasAuthorship W2044989255A5035900283 @default.
• W2044989255 hasAuthorship W2044989255A5051699127 @default.
• W2044989255 hasAuthorship W2044989255A5054809884 @default.
• W2044989255 hasBestOaLocation W20449892551 @default.
• W2044989255 hasConcept C126322002 @default.
• W2044989255 hasConcept C134018914 @default.
• W2044989255 hasConcept C185592680 @default.
• W2044989255 hasConcept C2781123555 @default.
• W2044989255 hasConcept C71924100 @default.
• W2044989255 hasConcept C86803240 @default.
• W2044989255 hasConceptScore W2044989255C126322002 @default.
• W2044989255 hasConceptScore W2044989255C134018914 @default.
• W2044989255 hasConceptScore W2044989255C185592680 @default.
• W2044989255 hasConceptScore W2044989255C2781123555 @default.
• W2044989255 hasConceptScore W2044989255C71924100 @default.
• W2044989255 hasConceptScore W2044989255C86803240 @default.
• W2044989255 hasIssue "3" @default.
• W2044989255 hasLocation W20449892551 @default.
• W2044989255 hasLocation W20449892552 @default.
• W2044989255 hasOpenAccess W2044989255 @default.
• W2044989255 hasPrimaryLocation W20449892551 @default.
• W2044989255 hasRelatedWork W1966504330 @default.
• W2044989255 hasRelatedWork W1966775726 @default.
• W2044989255 hasRelatedWork W1979139803 @default.
• W2044989255 hasRelatedWork W1986939346 @default.
• W2044989255 hasRelatedWork W2030889776 @default.
• W2044989255 hasRelatedWork W2037631372 @default.
• W2044989255 hasRelatedWork W2040058909 @default.
• W2044989255 hasRelatedWork W2132898409 @default.
• W2044989255 hasRelatedWork W2748952813 @default.
• W2044989255 hasRelatedWork W4249176446 @default.
• W2044989255 hasVolume "32" @default.
• W2044989255 isParatext "false" @default.
• W2044989255 isRetracted "false" @default.
• W2044989255 magId "2044989255" @default.
• W2044989255 workType "article" @default.