FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044989901> ?p ?o ?g. }

• W2044989901 endingPage "180" @default.
• W2044989901 startingPage "171" @default.
• W2044989901 abstract "Lipid peroxidation is one of the most important sources of endogenous toxic metabolites. 4-Hydroxy-2-nonenal (HNE) and 4-hydroxy-2-hexenal (HHE) are produced in several oxidative stress associated diseases from peroxidation of n-6 and n-3 polyunsaturated fatty acids, respectively. Both are able to form covalent adducts with many biomolecules. Particularly, proteins adduction can induce structural and conformational changes and impair biological function, which may be involved in the toxicity of hydroxy-alkenals. The aim of this study was to compare the effect of 4-hydroxy-2-alkenals to several chemically related derivatives in order to clarify the physico-chemical requirement of their toxicity. L6 muscle cells were treated with HHE, HNE and parent derivatives (acetal derivative, trans-alkenals and alkanals). Viability and necrosis were estimated using MTT, LDH and caspase-3 tests. LogLC50 (Lethal Concentration 50) was then tested for correlation with adducts formation (estimated using dinitrophenylhydrazine) and several molecular descriptors in order to establish quantitative structure-toxicity relationship (QSTR) models. The rank of derivatives toxicity, based on LC50 was: hydroxy-alkenals>acetal derivatives approximately 2-alkenals>alkanals and a high correlation was found between logLC50 and protein carbonylation. Moreover, logLC50 was correlated to the electrophilic descriptor LUMO (lowest unoccupied molecular orbital) as well as with electronegativity-related molecular descriptors such as number of oxygen atoms, partial negative surface area (PNSA3) and partial positive surface area (PPSA3). Together, these results point out the important role of the electrophilic structure and adduct formation in hydroxy-alkenals toxicity. Our present study demonstrates that 4-hydroxy-2-alkenals dramatic effects on cell viability are due to covalent adducts formation, particularly Michael adducts. This capacity is related to the electrophilic structure and reactive CC double bond, making it highly accessible for nucleophilic addition. The present study suggests that nucleophilic scavengers might protect cells against electrophile compounds and might be of possible therapeutic value in oxidative stress associated diseases." @default.
• W2044989901 created "2016-06-24" @default.
• W2044989901 creator A5002894950 @default.
• W2044989901 creator A5005320821 @default.
• W2044989901 creator A5021381890 @default.
• W2044989901 creator A5031391528 @default.
• W2044989901 creator A5035380494 @default.
• W2044989901 creator A5046706780 @default.
• W2044989901 creator A5057233389 @default.
• W2044989901 creator A5082661190 @default.
• W2044989901 creator A5088971388 @default.
• W2044989901 date "2010-10-01" @default.
• W2044989901 modified "2023-09-23" @default.
• W2044989901 title "Quantitative structure–activity relationship for 4-hydroxy-2-alkenal induced cytotoxicity in L6 muscle cells" @default.
• W2044989901 cites W1900846504 @default.
• W2044989901 cites W1963712961 @default.
• W2044989901 cites W1968603358 @default.
• W2044989901 cites W1972060936 @default.
• W2044989901 cites W1975625825 @default.
• W2044989901 cites W1980856980 @default.
• W2044989901 cites W1989262583 @default.
• W2044989901 cites W1992377755 @default.
• W2044989901 cites W1996639535 @default.
• W2044989901 cites W1999917690 @default.
• W2044989901 cites W2003323292 @default.
• W2044989901 cites W2008574812 @default.
• W2044989901 cites W2015255727 @default.
• W2044989901 cites W2023074303 @default.
• W2044989901 cites W2028547046 @default.
• W2044989901 cites W2029545130 @default.
• W2044989901 cites W2030219661 @default.
• W2044989901 cites W2035211778 @default.
• W2044989901 cites W2039518578 @default.
• W2044989901 cites W2040541235 @default.
• W2044989901 cites W2041942732 @default.
• W2044989901 cites W2043250256 @default.
• W2044989901 cites W2043836955 @default.
• W2044989901 cites W2049782053 @default.
• W2044989901 cites W2053542703 @default.
• W2044989901 cites W2055524718 @default.
• W2044989901 cites W2055807001 @default.
• W2044989901 cites W2058512158 @default.
• W2044989901 cites W2062742554 @default.
• W2044989901 cites W2063116304 @default.
• W2044989901 cites W2070046033 @default.
• W2044989901 cites W2076519801 @default.
• W2044989901 cites W2083451595 @default.
• W2044989901 cites W2087882379 @default.
• W2044989901 cites W2088696349 @default.
• W2044989901 cites W2090007062 @default.
• W2044989901 cites W2091193302 @default.
• W2044989901 cites W2110569594 @default.
• W2044989901 cites W2110657098 @default.
• W2044989901 cites W2112621466 @default.
• W2044989901 cites W2124821727 @default.
• W2044989901 cites W2138198801 @default.
• W2044989901 cites W2140126848 @default.
• W2044989901 cites W2141547031 @default.
• W2044989901 cites W2144586857 @default.
• W2044989901 cites W2145932267 @default.
• W2044989901 cites W2163511477 @default.
• W2044989901 cites W2165265330 @default.
• W2044989901 cites W2180600996 @default.
• W2044989901 cites W4233761810 @default.
• W2044989901 doi "https://doi.org/10.1016/j.cbi.2010.06.015" @default.
• W2044989901 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20619253" @default.
• W2044989901 hasPublicationYear "2010" @default.
• W2044989901 type Work @default.
• W2044989901 sameAs 2044989901 @default.
• W2044989901 citedByCount "26" @default.
• W2044989901 countsByYear W20449899012012 @default.
• W2044989901 countsByYear W20449899012013 @default.
• W2044989901 countsByYear W20449899012014 @default.
• W2044989901 countsByYear W20449899012015 @default.
• W2044989901 countsByYear W20449899012016 @default.
• W2044989901 countsByYear W20449899012017 @default.
• W2044989901 countsByYear W20449899012018 @default.
• W2044989901 countsByYear W20449899012020 @default.
• W2044989901 countsByYear W20449899012021 @default.
• W2044989901 countsByYear W20449899012022 @default.
• W2044989901 countsByYear W20449899012023 @default.
• W2044989901 crossrefType "journal-article" @default.
• W2044989901 hasAuthorship W2044989901A5002894950 @default.
• W2044989901 hasAuthorship W2044989901A5005320821 @default.
• W2044989901 hasAuthorship W2044989901A5021381890 @default.
• W2044989901 hasAuthorship W2044989901A5031391528 @default.
• W2044989901 hasAuthorship W2044989901A5035380494 @default.
• W2044989901 hasAuthorship W2044989901A5046706780 @default.
• W2044989901 hasAuthorship W2044989901A5057233389 @default.
• W2044989901 hasAuthorship W2044989901A5082661190 @default.
• W2044989901 hasAuthorship W2044989901A5088971388 @default.
• W2044989901 hasConcept C108204754 @default.
• W2044989901 hasConcept C109316439 @default.
• W2044989901 hasConcept C161790260 @default.
• W2044989901 hasConcept C178790620 @default.
• W2044989901 hasConcept C185592680 @default.
• W2044989901 hasConcept C19038510 @default.
• W2044989901 hasConcept C202751555 @default.

• next