Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044993806> ?p ?o ?g. }
- W2044993806 endingPage "327" @default.
- W2044993806 startingPage "321" @default.
- W2044993806 abstract "Ischemia–reperfusion injury (IRI) was one of the main causes of acute kidney injury. Mir-26a has been reported to play functions in cellular differentiation, cell growth, cell apoptosis and metastasis. Furthermore, the renal vein levels of Mir-26a were demonstrated to be lower in the poststenotic kidney. However, the effect of Mir-26a on the renal IRI has never been investigated. In our current study, Mir-26a overexpression results in attenuated renal IRI and promoted tregs expansion. The promoted renal function after IRI induced by Mir-26a overexpression was abrogated by depletion of tregs with anti-CD25 antibodies. Mir-26a also significantly suppressed IL-6 expression. And IL-6 overexpression led to significant suppression of the Mir-26a-induced upregulation of Foxp3. Next, we performed additional experiments to determine the therapeutic potential of Mir-26a during the recovery phase after renal IRI. Results showed that Mir-26a treatment after IRI also induced significant expansion of Foxp3+CD4+ Tregs in both spleen and renal on day 10 after IRI. Taken together, our data indicate an important role for Mir-26a in promoting tregs expansion in renal IRI that involving repression of IL-6 expression." @default.
- W2044993806 created "2016-06-24" @default.
- W2044993806 creator A5036283284 @default.
- W2044993806 creator A5056007719 @default.
- W2044993806 creator A5076427021 @default.
- W2044993806 date "2015-06-01" @default.
- W2044993806 modified "2023-09-27" @default.
- W2044993806 title "MicroRNA 26a modulates regulatory T cells expansion and attenuates renal ischemia–reperfusion injury" @default.
- W2044993806 cites W1545517148 @default.
- W2044993806 cites W1548761095 @default.
- W2044993806 cites W1554136447 @default.
- W2044993806 cites W1656464030 @default.
- W2044993806 cites W1752304426 @default.
- W2044993806 cites W1842545013 @default.
- W2044993806 cites W1909391377 @default.
- W2044993806 cites W1910489249 @default.
- W2044993806 cites W1980780108 @default.
- W2044993806 cites W1986347387 @default.
- W2044993806 cites W1991851120 @default.
- W2044993806 cites W2001482654 @default.
- W2044993806 cites W2010708756 @default.
- W2044993806 cites W2018599516 @default.
- W2044993806 cites W2042952613 @default.
- W2044993806 cites W2044720787 @default.
- W2044993806 cites W2047493201 @default.
- W2044993806 cites W2048178760 @default.
- W2044993806 cites W2053763669 @default.
- W2044993806 cites W2055132644 @default.
- W2044993806 cites W2075372904 @default.
- W2044993806 cites W2083796374 @default.
- W2044993806 cites W2097811455 @default.
- W2044993806 cites W2099850606 @default.
- W2044993806 cites W2120010406 @default.
- W2044993806 cites W2120313632 @default.
- W2044993806 cites W2124504284 @default.
- W2044993806 cites W2126825868 @default.
- W2044993806 cites W2127999139 @default.
- W2044993806 cites W2130979840 @default.
- W2044993806 cites W2144016326 @default.
- W2044993806 cites W2145030204 @default.
- W2044993806 cites W2148276874 @default.
- W2044993806 cites W2149576310 @default.
- W2044993806 cites W2150692938 @default.
- W2044993806 cites W2155779547 @default.
- W2044993806 cites W2157223085 @default.
- W2044993806 cites W2162819001 @default.
- W2044993806 cites W2164655249 @default.
- W2044993806 cites W2165167811 @default.
- W2044993806 cites W2371948111 @default.
- W2044993806 cites W2772222670 @default.
- W2044993806 doi "https://doi.org/10.1016/j.molimm.2015.02.003" @default.
- W2044993806 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25728641" @default.
- W2044993806 hasPublicationYear "2015" @default.
- W2044993806 type Work @default.
- W2044993806 sameAs 2044993806 @default.
- W2044993806 citedByCount "27" @default.
- W2044993806 countsByYear W20449938062015 @default.
- W2044993806 countsByYear W20449938062016 @default.
- W2044993806 countsByYear W20449938062017 @default.
- W2044993806 countsByYear W20449938062018 @default.
- W2044993806 countsByYear W20449938062019 @default.
- W2044993806 countsByYear W20449938062020 @default.
- W2044993806 countsByYear W20449938062021 @default.
- W2044993806 countsByYear W20449938062022 @default.
- W2044993806 crossrefType "journal-article" @default.
- W2044993806 hasAuthorship W2044993806A5036283284 @default.
- W2044993806 hasAuthorship W2044993806A5056007719 @default.
- W2044993806 hasAuthorship W2044993806A5076427021 @default.
- W2044993806 hasConcept C104317684 @default.
- W2044993806 hasConcept C126322002 @default.
- W2044993806 hasConcept C127561419 @default.
- W2044993806 hasConcept C145059251 @default.
- W2044993806 hasConcept C159641895 @default.
- W2044993806 hasConcept C185592680 @default.
- W2044993806 hasConcept C190283241 @default.
- W2044993806 hasConcept C203014093 @default.
- W2044993806 hasConcept C2779727006 @default.
- W2044993806 hasConcept C2780091579 @default.
- W2044993806 hasConcept C2780114680 @default.
- W2044993806 hasConcept C2780472472 @default.
- W2044993806 hasConcept C2780721119 @default.
- W2044993806 hasConcept C502942594 @default.
- W2044993806 hasConcept C541997718 @default.
- W2044993806 hasConcept C55493867 @default.
- W2044993806 hasConcept C71924100 @default.
- W2044993806 hasConcept C8891405 @default.
- W2044993806 hasConceptScore W2044993806C104317684 @default.
- W2044993806 hasConceptScore W2044993806C126322002 @default.
- W2044993806 hasConceptScore W2044993806C127561419 @default.
- W2044993806 hasConceptScore W2044993806C145059251 @default.
- W2044993806 hasConceptScore W2044993806C159641895 @default.
- W2044993806 hasConceptScore W2044993806C185592680 @default.
- W2044993806 hasConceptScore W2044993806C190283241 @default.
- W2044993806 hasConceptScore W2044993806C203014093 @default.
- W2044993806 hasConceptScore W2044993806C2779727006 @default.
- W2044993806 hasConceptScore W2044993806C2780091579 @default.
- W2044993806 hasConceptScore W2044993806C2780114680 @default.
- W2044993806 hasConceptScore W2044993806C2780472472 @default.