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• W2044996946 abstract "In order to assess the relationship between human immunodeficiency virus (HIV) RNA, hepatitis C virus (HCV) RNA, CD4, CD8, and liver enzymes during combination antiretroviral therapy, these parameters were measured in 12 HIV-HCV-coinfected patients (who were naive for antiretrovirals) on the day before and 3, 7, 14, 28, 56, and 84 days after initiating the following treatments: stavudine and lamivudine in all patients, indinavir in 6 patients, and nevirapine in 6 patients. HIV RNA declined rapidly, CD4 cells increased slowly, and CD8 cells and liver enzymes were stable. HCV RNA showed a transient significant increase at days 14 and 21 (7.33 ± 0.16 [mean ± SE] and 7.29 ± 0.2 log copies/mL vs. 7 ± 0.2 log copies/mL at baseline; P < .05). These changes were similar in both treatment groups. A 2-fold alanine aminotransferase increase was observed in 4 of 12 patients; 4 of 4 patients showed increased HCV RNA. The relationship between HCV RNA increase and HIV RNA decrease indicates virus-virus interference. An HCV RNA increase may cause significant liver damage only in a minority of patients." @default.
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• W2044996946 date "2000-06-01" @default.
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• W2044996946 title "Liver Damage and Kinetics of Hepatitis C Virus and Human Immunodeficiency Virus Replication during the Early Phases of Combination Antiretroviral Treatment" @default.
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• W2044996946 doi "https://doi.org/10.1086/315529" @default.
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