FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044998049> ?p ?o ?g. }

• W2044998049 endingPage "141" @default.
• W2044998049 startingPage "131" @default.
• W2044998049 abstract "Two IgG2a monoclonal antibodies (G10 and F11) are described which have similar affinity for human spleen ferritin and identical protein A-binding affinity. The two mAbs display changes in protein A-binding affinity following binding of the antigen to its specific recognition site in the variable domains. However, while antigen-induced conformational changes in G10 enhance its affinity to protein A, interaction of F11 with ferritin results in a significant decrease in protein A-binding affinity. In contrast to the IgG2a antibodies, using a mouse IgG1 antiferritin antibody (C5) high-affinity binding of the antigen does not change an inherently low ability to bind protein A. Differential scanning calorimetry revealed that the enthalpy and Gibb's free energy of thermal unfolding for G10 was 19% and 23% higher, respectively, than the corresponding parameters for F11. The lower structural energetics of F11 are associated with the absence of a calorimetrically revealed folding unit, which may be responsible for interactions between the antigen-binding site and the protein A-binding site. This study provides the first demonstration that functionally significant interactions between two recognition sites in antibodies of the same subclass can be modulated by subclass-independent structural variations associated with different thermodynamic stability." @default.
• W2044998049 created "2016-06-24" @default.
• W2044998049 creator A5010340872 @default.
• W2044998049 creator A5037775270 @default.
• W2044998049 creator A5053820301 @default.
• W2044998049 creator A5058873637 @default.
• W2044998049 date "1998-08-01" @default.
• W2044998049 modified "2023-10-14" @default.
• W2044998049 title "Two high-affinity monoclonal IgG2a antibodies with differing thermodynamic stability demonstrate distinct antigen-induced changes in protein A-binding affinity" @default.
• W2044998049 cites W1561925924 @default.
• W2044998049 cites W1588758282 @default.
• W2044998049 cites W1596476497 @default.
• W2044998049 cites W1972618236 @default.
• W2044998049 cites W1977461031 @default.
• W2044998049 cites W2010890576 @default.
• W2044998049 cites W2017595356 @default.
• W2044998049 cites W2021900417 @default.
• W2044998049 cites W2030453363 @default.
• W2044998049 cites W2043265064 @default.
• W2044998049 cites W2044110936 @default.
• W2044998049 cites W2058426435 @default.
• W2044998049 cites W2062895505 @default.
• W2044998049 cites W2069795445 @default.
• W2044998049 cites W2073941986 @default.
• W2044998049 cites W2078933151 @default.
• W2044998049 cites W2091938565 @default.
• W2044998049 cites W2092562610 @default.
• W2044998049 cites W2093912810 @default.
• W2044998049 cites W2100837269 @default.
• W2044998049 cites W2115414533 @default.
• W2044998049 cites W2141003188 @default.
• W2044998049 cites W2142533898 @default.
• W2044998049 cites W2148101204 @default.
• W2044998049 cites W2148404862 @default.
• W2044998049 cites W2159392498 @default.
• W2044998049 cites W2171610577 @default.
• W2044998049 cites W28039676 @default.
• W2044998049 cites W4253085957 @default.
• W2044998049 cites W4293253343 @default.
• W2044998049 cites W4300941906 @default.
• W2044998049 doi "https://doi.org/10.1016/s0022-1759(98)00110-0" @default.
• W2044998049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9776583" @default.
• W2044998049 hasPublicationYear "1998" @default.
• W2044998049 type Work @default.
• W2044998049 sameAs 2044998049 @default.
• W2044998049 citedByCount "15" @default.
• W2044998049 countsByYear W20449980492014 @default.
• W2044998049 crossrefType "journal-article" @default.
• W2044998049 hasAuthorship W2044998049A5010340872 @default.
• W2044998049 hasAuthorship W2044998049A5037775270 @default.
• W2044998049 hasAuthorship W2044998049A5053820301 @default.
• W2044998049 hasAuthorship W2044998049A5058873637 @default.
• W2044998049 hasConcept C107824862 @default.
• W2044998049 hasConcept C121332964 @default.
• W2044998049 hasConcept C12554922 @default.
• W2044998049 hasConcept C135604509 @default.
• W2044998049 hasConcept C147483822 @default.
• W2044998049 hasConcept C153911025 @default.
• W2044998049 hasConcept C159654299 @default.
• W2044998049 hasConcept C185592680 @default.
• W2044998049 hasConcept C203014093 @default.
• W2044998049 hasConcept C2776194381 @default.
• W2044998049 hasConcept C2778319317 @default.
• W2044998049 hasConcept C39519442 @default.
• W2044998049 hasConcept C542903549 @default.
• W2044998049 hasConcept C55493867 @default.
• W2044998049 hasConcept C86803240 @default.
• W2044998049 hasConcept C97355855 @default.
• W2044998049 hasConceptScore W2044998049C107824862 @default.
• W2044998049 hasConceptScore W2044998049C121332964 @default.
• W2044998049 hasConceptScore W2044998049C12554922 @default.
• W2044998049 hasConceptScore W2044998049C135604509 @default.
• W2044998049 hasConceptScore W2044998049C147483822 @default.
• W2044998049 hasConceptScore W2044998049C153911025 @default.
• W2044998049 hasConceptScore W2044998049C159654299 @default.
• W2044998049 hasConceptScore W2044998049C185592680 @default.
• W2044998049 hasConceptScore W2044998049C203014093 @default.
• W2044998049 hasConceptScore W2044998049C2776194381 @default.
• W2044998049 hasConceptScore W2044998049C2778319317 @default.
• W2044998049 hasConceptScore W2044998049C39519442 @default.
• W2044998049 hasConceptScore W2044998049C542903549 @default.
• W2044998049 hasConceptScore W2044998049C55493867 @default.
• W2044998049 hasConceptScore W2044998049C86803240 @default.
• W2044998049 hasConceptScore W2044998049C97355855 @default.
• W2044998049 hasIssue "1-2" @default.
• W2044998049 hasLocation W20449980491 @default.
• W2044998049 hasLocation W20449980492 @default.
• W2044998049 hasOpenAccess W2044998049 @default.
• W2044998049 hasPrimaryLocation W20449980491 @default.
• W2044998049 hasRelatedWork W1511067427 @default.
• W2044998049 hasRelatedWork W1549155385 @default.
• W2044998049 hasRelatedWork W2009011029 @default.
• W2044998049 hasRelatedWork W2025265121 @default.
• W2044998049 hasRelatedWork W2037210200 @default.
• W2044998049 hasRelatedWork W2060980616 @default.
• W2044998049 hasRelatedWork W2078166982 @default.
• W2044998049 hasRelatedWork W3015925659 @default.
• W2044998049 hasRelatedWork W3135151721 @default.

• next