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- W2044998086 abstract "The proposed research is a continuation of the work conducted under this contract and is outlined. During this year, the main emphasis will be given to study further the properties of HO/sub 2/ and O/sub 2//sup -/ and OH, mainly in their role in biological systems. We will continue to study and elucidate how O/sub 2//sup -/ reacts in biological systems. The toxicity of O/sub 2//sup -/ is quite well established, but the mechanism is still obscure. The Haber Weiss reaction most probably can not account for the toxicity of O/sub 2//sup -/ nor for the formation of singlet oxygen, nor of OH. We will study if reduction of Fe/sup 3 +/ complexes by O/sub 2//sup -/ in biological systems does catalyze the Haber Weiss reaction and if OH is formed in this mechanism. The role of oxygen, radiosensitizers in radiation damage of bacteriophages and cells will be further studied, as well as on E. Coli and Enzymes. We will try to elucidate the formation and role of OH, O/sub 2//sup -/ and O/sub 2/ in these systems as well as the relative contribution of endogenous and exogenous damage, and the role of direct and indirect radiation damage to cells. We intend also to study if SOD (super oxide dismutase) does react only with O/sub 2//sup -/ or also with biological peroxides (RO/sub 2/) and Hydroperoxides (RO/sub 2/H). Further studies of O/sub 2//sup -/ and O/sub 2/ with various cytochromes, and hemoglobins is planned." @default.
- W2044998086 created "2016-06-24" @default.
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- W2044998086 date "1979-01-01" @default.
- W2044998086 modified "2023-10-18" @default.
- W2044998086 title "Nature of oxygen containing radicals in radiation chemistry and photochemistry of aqueous solutions. Annual progress report, September 1978--July 1979" @default.
- W2044998086 doi "https://doi.org/10.2172/5896039" @default.
- W2044998086 hasPublicationYear "1979" @default.
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