Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045000597> ?p ?o ?g. }
- W2045000597 endingPage "308" @default.
- W2045000597 startingPage "298" @default.
- W2045000597 abstract "One of the most exciting developments in our understanding of atrial fibrillation (AF) over the last several years has been the recognition that AF itself modifies atrial electrical properties in a way that promotes the occurrence and maintenance of the arrhythmia, a process termed ‘atrial remodeling’. The principle stimulus for AF-induced atrial remodeling is the rapid atrial rate that results: rapid regular atrial pacing produces changes similar to those caused by AF in animal models. The mechanisms of atrial tachycardia-induced remodeling have been extensively explored, and involve changes in atrial electrophysiology associated with altered ion channel function. The most important ionic change is a reduction in L-type Ca2+ current, which reduces action potential duration (APD) and APD adaptation to rate. AF-induced changes in ion channel function appear to be due both to rapid voltage- and time-dependent alterations in channel availability caused by tachycardia and to slower downregulation of messenger RNA concentrations encoding α-subunits of specific ion channels. Atrial remodeling likely contributes importantly to a wide variety of clinical phenomena of previously unrecognized mechanism, including atrial dysfunction after cardioversion of AF, the increasing resistance to therapy of longer-standing AF, the association of AF with other forms of supraventricular tachyarrhythmia and the tendency of paroxysmal AF to become chronic. The present paper reviews the state of knowledge regarding the mechanisms and clinical consequences for AF of atrial remodeling caused by rapid atrial activation." @default.
- W2045000597 created "2016-06-24" @default.
- W2045000597 creator A5064311226 @default.
- W2045000597 date "1999-05-01" @default.
- W2045000597 modified "2023-10-17" @default.
- W2045000597 title "Atrial electrophysiological remodeling caused by rapid atrial activation: underlying mechanisms and clinical relevance to atrial fibrillation" @default.
- W2045000597 cites W1509769147 @default.
- W2045000597 cites W1531679198 @default.
- W2045000597 cites W1561086309 @default.
- W2045000597 cites W1754352567 @default.
- W2045000597 cites W1849816754 @default.
- W2045000597 cites W1952117966 @default.
- W2045000597 cites W1964999753 @default.
- W2045000597 cites W1966526405 @default.
- W2045000597 cites W1967004379 @default.
- W2045000597 cites W1967351353 @default.
- W2045000597 cites W1971397909 @default.
- W2045000597 cites W1978001275 @default.
- W2045000597 cites W1985547906 @default.
- W2045000597 cites W1989158067 @default.
- W2045000597 cites W1991397305 @default.
- W2045000597 cites W1996393395 @default.
- W2045000597 cites W1996411027 @default.
- W2045000597 cites W1997344308 @default.
- W2045000597 cites W2000752865 @default.
- W2045000597 cites W2007887497 @default.
- W2045000597 cites W2009414043 @default.
- W2045000597 cites W2012609446 @default.
- W2045000597 cites W2017179259 @default.
- W2045000597 cites W2027709297 @default.
- W2045000597 cites W2032227708 @default.
- W2045000597 cites W2032884759 @default.
- W2045000597 cites W2034122339 @default.
- W2045000597 cites W2034282563 @default.
- W2045000597 cites W2049375834 @default.
- W2045000597 cites W2050688237 @default.
- W2045000597 cites W2058967452 @default.
- W2045000597 cites W2066166072 @default.
- W2045000597 cites W2066507239 @default.
- W2045000597 cites W2066886554 @default.
- W2045000597 cites W2067537913 @default.
- W2045000597 cites W2073015884 @default.
- W2045000597 cites W2078125895 @default.
- W2045000597 cites W2078686071 @default.
- W2045000597 cites W2082272659 @default.
- W2045000597 cites W2082510854 @default.
- W2045000597 cites W2084719078 @default.
- W2045000597 cites W2102450596 @default.
- W2045000597 cites W2103549163 @default.
- W2045000597 cites W2104749146 @default.
- W2045000597 cites W2116424591 @default.
- W2045000597 cites W2117176106 @default.
- W2045000597 cites W2136753204 @default.
- W2045000597 cites W2140145766 @default.
- W2045000597 cites W2143283669 @default.
- W2045000597 cites W2165006299 @default.
- W2045000597 cites W2284326175 @default.
- W2045000597 cites W2313203550 @default.
- W2045000597 cites W2336460456 @default.
- W2045000597 cites W2472296230 @default.
- W2045000597 cites W2554105837 @default.
- W2045000597 cites W47281674 @default.
- W2045000597 cites W610413049 @default.
- W2045000597 cites W2050795671 @default.
- W2045000597 cites W2417905337 @default.
- W2045000597 doi "https://doi.org/10.1016/s0008-6363(99)00022-x" @default.
- W2045000597 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10533568" @default.
- W2045000597 hasPublicationYear "1999" @default.
- W2045000597 type Work @default.
- W2045000597 sameAs 2045000597 @default.
- W2045000597 citedByCount "138" @default.
- W2045000597 countsByYear W20450005972012 @default.
- W2045000597 countsByYear W20450005972013 @default.
- W2045000597 countsByYear W20450005972014 @default.
- W2045000597 countsByYear W20450005972015 @default.
- W2045000597 countsByYear W20450005972016 @default.
- W2045000597 countsByYear W20450005972017 @default.
- W2045000597 countsByYear W20450005972018 @default.
- W2045000597 countsByYear W20450005972019 @default.
- W2045000597 countsByYear W20450005972020 @default.
- W2045000597 countsByYear W20450005972021 @default.
- W2045000597 countsByYear W20450005972022 @default.
- W2045000597 crossrefType "journal-article" @default.
- W2045000597 hasAuthorship W2045000597A5064311226 @default.
- W2045000597 hasBestOaLocation W20450005971 @default.
- W2045000597 hasConcept C126322002 @default.
- W2045000597 hasConcept C146403970 @default.
- W2045000597 hasConcept C164705383 @default.
- W2045000597 hasConcept C185263204 @default.
- W2045000597 hasConcept C2776131983 @default.
- W2045000597 hasConcept C2779161974 @default.
- W2045000597 hasConcept C2779422446 @default.
- W2045000597 hasConcept C71924100 @default.
- W2045000597 hasConcept C87520248 @default.
- W2045000597 hasConceptScore W2045000597C126322002 @default.
- W2045000597 hasConceptScore W2045000597C146403970 @default.
- W2045000597 hasConceptScore W2045000597C164705383 @default.
- W2045000597 hasConceptScore W2045000597C185263204 @default.