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- W2045002282 abstract "Objective: We conducted this study to evaluate the association of cytokine genotypes and sputum concentrations on longitudinal decline in lung function in firefighters. Methods: In 67 firefighters with at least four pulmonary function tests, DNA was analyzed for functional polymorphisms of interleukin (IL)-1β, IL-1 receptor antagonist (IL-1RA), IL-8, IL-10, tumor necrosis factor-alpha (TNF-α) genes, and sputum evaluated for cytokine concentration by ELISA. Results: The annual rate of FEV1 decline was greater in firefighters with TT genotypes at IL-10 (−819) (P = 0.009) and with CT or TT genotypes at IL-1RA (2018) (P = 0.050). These genotypes were not associated with concentrations of sputum cytokine, but increased IL-1RA was associated with a slower rate of FEV1 decline (P = 0.025), as was increased sputum macrophage count (P = 0.002). Conclusions: Cytokine genotypes were associated with the rate of FEV1 decline but did not alter concentrations of sputum cytokine. Increased sputum IL-1RA may be protective." @default.
- W2045002282 created "2016-06-24" @default.
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- W2045002282 date "2007-03-01" @default.
- W2045002282 modified "2023-10-12" @default.
- W2045002282 title "Cytokine Genotype and Phenotype Effects on Lung Function Decline in Firefighters" @default.
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- W2045002282 doi "https://doi.org/10.1097/jom.0b013e3180322584" @default.
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