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• W2045002816 abstract "• We studied the hippocampus dealing with different levels of difficulty in HE. • We used one-trial object-place recognition and reversal learning. • Behavioral results showed impairment in acquisition of both tasks. • HE group showed high c-Fos in CA1, CA3 and Ent in object task. • HE group showed a decrease in c-Fos in CA1, CA3, DG, CG, PL and IL in reversal. The hippocampus has been established as a site of plasticity during the acquisition of spatial memory. The memory for spatial locations is impaired in patients who develop hepatic encephalopathy (HE). We wondered how the hippocampus can manage different hippocampal-dependent tasks in a type B model of the early evolutive phases of HE induced by triple portal vein ligation. We used a one-trial object-place recognition task that involves making judgements about whether a stimulus was encountered before in that location and a reversal learning task performed in the Morris water maze that involves reward-guided behavior and decision making. Our behavioral results showed impairments in the acquisition of both tasks by the portal hypertension group compared with the sham-operated group. To label brain areas related to these tasks, we marked the expression of the c-Fos protein and revealed high c-Fos immunoreactivity in cornu ammonis 1 (CA1), cornu ammonis 3 (CA3) and entorhinal (Ent) cortex of the PH group compared with the SHAM group in the object-place recognition task and a decrease in c-Fos-positive cells in the reversal task in the CA1, CA3, dentate gyrus (DG), cingulate (CG), prelimbic (PL), and infralimbic (IL) cortices in the PH group compared with the SHAM group. In conclusion, the study corroborated the pivotal role of the hippocampus in spatial memory deficits found in the early stages of type B HE and noted its differential contribution in each of the tasks." @default.
• W2045002816 created "2016-06-24" @default.
• W2045002816 creator A5002964551 @default.
• W2045002816 creator A5041973188 @default.
• W2045002816 creator A5042984699 @default.
• W2045002816 date "2015-01-01" @default.
• W2045002816 modified "2023-09-27" @default.
• W2045002816 title "Differential contribution of the hippocampus in two different demanding tasks at early stages of hepatic encephalopathy" @default.
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• W2045002816 doi "https://doi.org/10.1016/j.neuroscience.2014.08.060" @default.
• W2045002816 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25290018" @default.
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