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- W2045004009 abstract "Abstract Young male, Sprague-Dawley rats, 60–70 days of age, and adult male Long-Evans rats, 1 yr old, were injected with povidone-iodine (Betadine) at two different dosages. The characteristic pattern of the Wolff-Chaikoff block followed exposure to the free iodine liberated by the povidone-iodine complex causing a reduction in thyroid 131I uptake, depression of the thyroid-to-serum radioiodide ratio, and inhibition of organic iodinations. The marked reduction in the percentages of labeled mono- and di-iodotyrosines (MIT and DIT), and iodothyronines (T3 + T4), the large increase in percentage of labeled iodide and the increase in MIT DIT ratios are changes which are considered as a classic illustration of the consequences of a reduction in thyroid hormone synthesis. This is an example of what is termed the Wolff-Chaikoff effect which usually follows the presence of high concentrations of inorganic iodine." @default.
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- W2045004009 date "1976-02-01" @default.
- W2045004009 modified "2023-09-23" @default.
- W2045004009 title "The effect of povidone-iodine on thyroid function in rats" @default.
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- W2045004009 doi "https://doi.org/10.1016/0041-008x(76)90293-3" @default.
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