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• W2045004770 abstract "Background and Objectives Predicting the prognosis in gastric carcinoma patients with intermediate stages is difficult. We investigated the prognostic impacts of CD44 and nm23 expression in a homogeneous group of patients with stage II and IIIA gastric carcinoma who had undergone curative resections. Methods A total of 261 paraffin-embedded gastric carcinomas were stained with the monoclonal antibodies CD44 and nm23 using the labeled streptovidin biotin method. Results The expression of CD44 and nm23 was detected, respectively, in 31.0% (81/261) and 70.1% (183/261) of all tumors. There was no correlation between CD44 expression and clinicopathological variables. However, nm23 was more frequently expressed in older patients with differentiated adenocarcinoma. A significant difference in 5-year survival rates was found between patients with CD44-positive (43.2%) and CD44-negative tumors (63.4%), (P = 0.0018). However, there was no significant difference in 5-year survival rates between patients with nm23-positive (54.7%) and nm23-negative tumors (62.7%) (P = 0.2734). Conclusions CD44 expression was a significant adverse prognostic factor in gastric carcinoma and may be a predictor of metastatic potential of the primary tumor. By contrast, immunohistochemical detection of nm23 expression was not a predictor of outcome of patients with gastric carcinoma. J. Surg. Oncol. 1999:71:22–28. © 1999 Wiley-Liss, Inc." @default.
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• W2045004770 date "1999-05-01" @default.
• W2045004770 modified "2023-10-16" @default.
• W2045004770 title "Prognostic significance of CD44 and nm23 expression in patients with stage II and stage IIIA gastric carcinoma" @default.
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• W2045004770 doi "https://doi.org/10.1002/(sici)1096-9098(199905)71:1<22::aid-jso5>3.0.co;2-i" @default.
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