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- W2045005550 abstract "A new quantitative and comprehensive approach relating structures of congeneric drugs to their relative biological activities is presented. The analysis is derived on the basis that structure-activity relationships represent a family, a different situation applying to each phenomenon such as drug absorption, drug transport, drug transformation, and drug excretion. The present treatment considers the relationship under equilibrium or quasiequilibrium conditions, thus permitting rigorous thermodynamic treatment. On the basis of the effect of structural changes on the distributive tendencies of the drug in various body tissues, including the receptor site, relationships have been derived which are surprisingly in good agreement with available experimental data. The approach suggests a rational way to predict the degree of lipophilicity which would result in maximal activity." @default.
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- W2045005550 title "Thermodynamic Analysis of Structure-Activity Relationships of Drugs: Prediction of Optimal Structure" @default.
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- W2045005550 doi "https://doi.org/10.1002/jps.2600591003" @default.
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