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• W2045009092 abstract "Individuals who abuse methamphetamine (MA) exhibit heightened aggression, but the neurobiological underpinnings are poorly understood. As variability in the serotonin transporter (SERT) gene can influence aggression, this study assessed possible contributions of this gene to MA-related aggression. In all, 53 MA-dependent and 47 control participants provided self-reports of aggression, and underwent functional magnetic resonance imaging while viewing pictures of faces. Participants were genotyped at two functional polymorphic loci in the SERT gene: the SERT-linked polymorphic region (SERT-LPR) and the intron 2 variable number tandem repeat polymorphism (STin2 VNTR); participants were then classified as having high or low risk for aggression according to individual SERT risk allele combinations. Comparison of SERT risk allele loads between groups showed no difference between MA-dependent and control participants. Comparison of self-report scores showed greater aggression in MA-dependent than control participants, and in high genetic risk than low-risk participants. Signal change in the amygdala was lower in high genetic risk than low-risk participants, but showed no main effect of MA abuse; however, signal change correlated negatively with MA use measures. Whole-brain differences in activation were observed between MA-dependent and control groups in the occipital and prefrontal cortex, and between genetic high- and low-risk groups in the occipital, fusiform, supramarginal and prefrontal cortex, with effects overlapping in a small region in the right ventrolateral prefrontal cortex. The findings suggest that the investigated SERT risk allele loads are comparable between MA-dependent and healthy individuals, and that MA and genetic risk influence aggression independently, with minimal overlap in associated neural substrates." @default.
• W2045009092 created "2016-06-24" @default.
• W2045009092 creator A5019337347 @default.
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• W2045009092 date "2012-02-21" @default.
• W2045009092 modified "2023-09-26" @default.
• W2045009092 title "Effects of methamphetamine abuse and serotonin transporter gene variants on aggression and emotion-processing neurocircuitry" @default.
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• W2045009092 cites W1965230752 @default.
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• W2045009092 cites W1976730458 @default.
• W2045009092 cites W1981918518 @default.
• W2045009092 cites W1984030600 @default.
• W2045009092 cites W1984455353 @default.
• W2045009092 cites W1988418074 @default.
• W2045009092 cites W1988671883 @default.
• W2045009092 cites W1988816787 @default.
• W2045009092 cites W1989475801 @default.
• W2045009092 cites W1989873034 @default.
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• W2045009092 cites W2005534453 @default.
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• W2045009092 cites W2116628589 @default.
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• W2045009092 doi "https://doi.org/10.1038/tp.2011.73" @default.
• W2045009092 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3309557" @default.
• W2045009092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22832817" @default.
• W2045009092 hasPublicationYear "2012" @default.
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