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- W2045017325 abstract "Abstract The hepatic cellular distribution in rats of radioiron and radiocarbon after [14C-gluconic acid] — and 59Fe-labelled iron-poly(sorbitol-gluconic acid) complex, glusoferron (Ferastral®), has been investigated. Following administration of the 59Fe-iron complex at a dose level corresponding to 10 mg of iron per kg bodyweight, the ratio of radioactivity per 108 cells in parenchymal (P) and non-parenchymal (NP) cell fractions, the P/NP ratio, was 3.0 after 24 hours and rose to 10.4 at day 14. After 100 mg/kg the ratio was 0.9, 10.5 and 5.7 at day 1,4 and 14, respectively. Radiocarbon content in the different cell compartments fell steadily throughout. Radioiron from 59Fe-iron-poly(sorbitol-gluconic acid) complex was shown to be incorporated into whole liver 59Fe-ferritin. In vitro uptake studies with the different liver cells were also performed. Parenchymal cells were found to be more active than non-parenchymal cells with regard to cellular uptake of radiolabel from both iron complex and polymeric ligand without iron." @default.
- W2045017325 created "2016-06-24" @default.
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- W2045017325 date "2009-03-13" @default.
- W2045017325 modified "2023-09-27" @default.
- W2045017325 title "Relative Contribution of Parenchymal and Non-parenchymal Cells to the Hepatic Distribution and Metabolism of Iron-poly(sorbitol-gluconic acid) Complex in the Rat" @default.
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- W2045017325 doi "https://doi.org/10.1111/j.1600-0773.1980.tb02465.x" @default.
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