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• W2045027770 abstract "Because of shared routes of transmission, 5–25% of the 34 million people with HIV worldwide are co-infected with either hepatitis B virus (HBV), hepatitis C virus (HCV), or both, 1 Hoffmann CJ Thio CL Clinical implications of HIV and hepatitis B co-infection in Asia and Africa. Lancet Infect Dis. 2007; 7: 402-409 Summary Full Text Full Text PDF PubMed Scopus (230) Google Scholar with the highest number of co-infections in low-income countries. The negative effect of HIV infection on the progression of HBV and HCV infection is well established, with high rates of viral persistence, higher hepatitis viral load, and a more rapid progression to liver fibrosis and hepatocellular carcinoma in HIV-positive patients. 2 Joshi D O'Grady J Dieterich D Gazzard B Agarwal K Increasing burden of liver disease in patients with HIV infection. Lancet. 2011; 377: 1198-1209 Summary Full Text Full Text PDF PubMed Scopus (207) Google Scholar In high-income countries, hepatic disease is the third highest cause of death in people with HIV after AIDS-related mortality and non-AIDS cancer deaths 3 Smith CJ Ryom L Weber R et al. Trends in underlying causes of death in people with HIV from 1999 to 2011 (D:A:D): a multicohort collaboration. Lancet. 2014; 384: 241-248 Summary Full Text Full Text PDF PubMed Scopus (623) Google Scholar , and hepatocellular carcinoma causes a quarter of liver-related deaths. 2 Joshi D O'Grady J Dieterich D Gazzard B Agarwal K Increasing burden of liver disease in patients with HIV infection. Lancet. 2011; 377: 1198-1209 Summary Full Text Full Text PDF PubMed Scopus (207) Google Scholar Because of the increasing availability of antiretroviral therapy and the high burden of viral hepatitis, chronic hepatitis and its consequences are expected to become a leading burden of disease in resource-limited countries, although the true prevalence and clinical evolution of liver disease in low-income and middle-income countries are still largely unknown. In highly endemic regions such as Africa and Asia, the prevalence of HBV is estimated to be as much as 8% (10–15% in some countries), and HBV infection mostly occurs early in life through vertical or child-to-child transmission; the effect of hepatocellular carcinoma is likely to be even greater than estimated, particularly in Asia where HBV genotype C is highly prevalent. 4 El-Serag HB Epidemiology of viral hepatitis and hepatocellular carcinoma. Gastroenterology. 2012; 142: 1264-1273 Summary Full Text Full Text PDF PubMed Scopus (2307) Google Scholar HIV, hepatitis B virus, and hepatitis C virus co-infection in patients in the China National Free Antiretroviral Treatment Program, 2010–12: a retrospective observational cohort studyScreening for viral hepatitis is important in individuals diagnosed as HIV positive. Effective management for viral hepatitis should be integrated into HIV treatment programmes. Long-term data are needed about the effect of hepatitis co-infection on HIV disease progression. Full-Text PDF" @default.
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• W2045027770 date "2014-11-01" @default.
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• W2045027770 title "Hepatitis virus and HIV interactions" @default.
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• W2045027770 doi "https://doi.org/10.1016/s1473-3099(14)70853-9" @default.
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