Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045028907> ?p ?o ?g. }
- W2045028907 endingPage "24716" @default.
- W2045028907 startingPage "24707" @default.
- W2045028907 abstract "MicroRNAs (miRNAs) act in post-transcriptional gene silencing and are proposed to function in a wide spectrum of pathologies, including cancers and viral diseases. Currently, to our knowledge, no detailed mechanistic characterization of small molecules that interrupt miRNA pathways have been reported. In screening a small chemical library, we identified compounds that suppress RNA interference activity in cultured cells. Two compounds were characterized; one impaired Dicer activity while the other blocked small RNA-loading into an Argonaute 2 (AGO2) complex. We developed a cell-based model of miRNA-dependent tumorigenesis, and using this model, we observed that treatment of cells with either of the two compounds effectively neutralized tumor growth. These findings indicate that miRNA pathway-suppressing small molecules could potentially reverse tumorigenesis." @default.
- W2045028907 created "2016-06-24" @default.
- W2045028907 creator A5038694369 @default.
- W2045028907 creator A5069473183 @default.
- W2045028907 creator A5080251578 @default.
- W2045028907 creator A5080524336 @default.
- W2045028907 creator A5087036578 @default.
- W2045028907 date "2010-08-01" @default.
- W2045028907 modified "2023-10-12" @default.
- W2045028907 title "Identification of Small Molecules That Suppress MicroRNA Function and Reverse Tumorigenesis" @default.
- W2045028907 cites W1964016865 @default.
- W2045028907 cites W1967007963 @default.
- W2045028907 cites W1969296875 @default.
- W2045028907 cites W1976840413 @default.
- W2045028907 cites W1979297613 @default.
- W2045028907 cites W1980718338 @default.
- W2045028907 cites W1980952225 @default.
- W2045028907 cites W1982250275 @default.
- W2045028907 cites W1982783106 @default.
- W2045028907 cites W1983489347 @default.
- W2045028907 cites W1985563073 @default.
- W2045028907 cites W1987435684 @default.
- W2045028907 cites W1994429466 @default.
- W2045028907 cites W2007103799 @default.
- W2045028907 cites W2013842709 @default.
- W2045028907 cites W2038454593 @default.
- W2045028907 cites W2038766179 @default.
- W2045028907 cites W2041237942 @default.
- W2045028907 cites W2042159800 @default.
- W2045028907 cites W2050066317 @default.
- W2045028907 cites W2051555720 @default.
- W2045028907 cites W2054109341 @default.
- W2045028907 cites W2058982772 @default.
- W2045028907 cites W2062290101 @default.
- W2045028907 cites W2066815768 @default.
- W2045028907 cites W2068742284 @default.
- W2045028907 cites W2068972828 @default.
- W2045028907 cites W2070647652 @default.
- W2045028907 cites W2070917799 @default.
- W2045028907 cites W2086227770 @default.
- W2045028907 cites W2094057765 @default.
- W2045028907 cites W2101543035 @default.
- W2045028907 cites W2104610341 @default.
- W2045028907 cites W2107101690 @default.
- W2045028907 cites W2117391818 @default.
- W2045028907 cites W2117933664 @default.
- W2045028907 cites W2119962312 @default.
- W2045028907 cites W2120048927 @default.
- W2045028907 cites W2135810600 @default.
- W2045028907 cites W2135836598 @default.
- W2045028907 cites W2135837360 @default.
- W2045028907 cites W2142067397 @default.
- W2045028907 cites W2144038313 @default.
- W2045028907 cites W2149848115 @default.
- W2045028907 cites W2154841861 @default.
- W2045028907 cites W2156133650 @default.
- W2045028907 cites W2160098916 @default.
- W2045028907 cites W2162674813 @default.
- W2045028907 cites W2163298186 @default.
- W2045028907 cites W2168006368 @default.
- W2045028907 cites W4236031470 @default.
- W2045028907 cites W4238545515 @default.
- W2045028907 doi "https://doi.org/10.1074/jbc.m109.062976" @default.
- W2045028907 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2915707" @default.
- W2045028907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20529860" @default.
- W2045028907 hasPublicationYear "2010" @default.
- W2045028907 type Work @default.
- W2045028907 sameAs 2045028907 @default.
- W2045028907 citedByCount "102" @default.
- W2045028907 countsByYear W20450289072012 @default.
- W2045028907 countsByYear W20450289072013 @default.
- W2045028907 countsByYear W20450289072014 @default.
- W2045028907 countsByYear W20450289072015 @default.
- W2045028907 countsByYear W20450289072016 @default.
- W2045028907 countsByYear W20450289072017 @default.
- W2045028907 countsByYear W20450289072018 @default.
- W2045028907 countsByYear W20450289072019 @default.
- W2045028907 countsByYear W20450289072020 @default.
- W2045028907 countsByYear W20450289072021 @default.
- W2045028907 countsByYear W20450289072022 @default.
- W2045028907 countsByYear W20450289072023 @default.
- W2045028907 crossrefType "journal-article" @default.
- W2045028907 hasAuthorship W2045028907A5038694369 @default.
- W2045028907 hasAuthorship W2045028907A5069473183 @default.
- W2045028907 hasAuthorship W2045028907A5080251578 @default.
- W2045028907 hasAuthorship W2045028907A5080524336 @default.
- W2045028907 hasAuthorship W2045028907A5087036578 @default.
- W2045028907 hasBestOaLocation W20450289071 @default.
- W2045028907 hasConcept C104317684 @default.
- W2045028907 hasConcept C119056186 @default.
- W2045028907 hasConcept C14036430 @default.
- W2045028907 hasConcept C145059251 @default.
- W2045028907 hasConcept C161624437 @default.
- W2045028907 hasConcept C166703698 @default.
- W2045028907 hasConcept C185592680 @default.
- W2045028907 hasConcept C201853390 @default.
- W2045028907 hasConcept C2191507 @default.
- W2045028907 hasConcept C2776802755 @default.