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• W2045046989 abstract "Significance ADP is best known as a constituent of nucleic acids and for its role in energy metabolism. ADP is also an important signaling molecule that activates cell surface receptors in a broad range of cells. ADP receptor antagonists are widely used to treat cardiovascular disease. We studied the signaling pathways activated by ADP receptors in endothelial cells, which form the lining of blood vessels. Vascular disease states cause abnormalities in endothelial function. We identified a critical role for the reactive oxygen species hydrogen peroxide (H 2 O 2 ) in mediating cellular responses to ADP. We discovered that P2Y1 ADP receptors promote transactivation of the receptor tyrosine kinase Flt3, suggesting a new mechanism whereby cancer chemotherapy with receptor tyrosine kinase inhibitors cause vascular dysfunction." @default.
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• W2045046989 date "2014-02-18" @default.
• W2045046989 modified "2023-10-13" @default.
• W2045046989 title "Central role for hydrogen peroxide in P2Y1 ADP receptor-mediated cellular responses in vascular endothelium" @default.
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• W2045046989 doi "https://doi.org/10.1073/pnas.1320854111" @default.
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