Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045051162> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2045051162 endingPage "517" @default.
- W2045051162 startingPage "513" @default.
- W2045051162 abstract "Psoriasis, a skin disease with autoimmune features, can be triggered and exacerbated by genetic and environmental factors. Chemicals can break tolerance to self-antigens by interfering with antigen processing and presentation; therefore, proteins involved in antigen processing may affect susceptibility. We test here whether variants of immunoproteasome subunits LMP2 and LMP7, or antigen peptide transport proteins TAP1 (transporters associated with antigen presentation) and TAP2 are associated with psoriasis. We analyzed 7 single-nucleotide polymorphisms in 321 Caucasian (German) psoriasis patients and 235 unrelated controls by time-of-flight mass spectrometry, using the Sequenom platform. We found strong associations of psoriasis with variant alleles of LMP and TAP (ORTAP_687: 3.3, 95% CI: 1.9–5.7). Genotype effects were generally stronger for males and LMP effects were mainly seen for psoriasis arthropathica. Our results will help define behavioral or drug treatment suggestions to patients and contribute to a better understanding of the role of low molecular weight chemicals in genetic susceptibility to autoimmune diseases." @default.
- W2045051162 created "2016-06-24" @default.
- W2045051162 creator A5004570682 @default.
- W2045051162 creator A5043645408 @default.
- W2045051162 creator A5071033298 @default.
- W2045051162 creator A5071887916 @default.
- W2045051162 creator A5087695782 @default.
- W2045051162 date "2007-06-21" @default.
- W2045051162 modified "2023-10-18" @default.
- W2045051162 title "Strong associations of psoriasis with antigen processing LMP and transport genes TAP differ by gender and phenotype" @default.
- W2045051162 cites W2021336638 @default.
- W2045051162 cites W2023852458 @default.
- W2045051162 cites W2025826537 @default.
- W2045051162 cites W2025888803 @default.
- W2045051162 cites W2035233767 @default.
- W2045051162 cites W2043151506 @default.
- W2045051162 cites W2090708593 @default.
- W2045051162 cites W2098701094 @default.
- W2045051162 cites W2103771558 @default.
- W2045051162 cites W2793859699 @default.
- W2045051162 cites W3020852038 @default.
- W2045051162 cites W4250618101 @default.
- W2045051162 doi "https://doi.org/10.1038/sj.gene.6364404" @default.
- W2045051162 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17581627" @default.
- W2045051162 hasPublicationYear "2007" @default.
- W2045051162 type Work @default.
- W2045051162 sameAs 2045051162 @default.
- W2045051162 citedByCount "26" @default.
- W2045051162 countsByYear W20450511622012 @default.
- W2045051162 countsByYear W20450511622013 @default.
- W2045051162 countsByYear W20450511622014 @default.
- W2045051162 countsByYear W20450511622015 @default.
- W2045051162 countsByYear W20450511622017 @default.
- W2045051162 countsByYear W20450511622018 @default.
- W2045051162 countsByYear W20450511622020 @default.
- W2045051162 countsByYear W20450511622021 @default.
- W2045051162 crossrefType "journal-article" @default.
- W2045051162 hasAuthorship W2045051162A5004570682 @default.
- W2045051162 hasAuthorship W2045051162A5043645408 @default.
- W2045051162 hasAuthorship W2045051162A5071033298 @default.
- W2045051162 hasAuthorship W2045051162A5071887916 @default.
- W2045051162 hasAuthorship W2045051162A5087695782 @default.
- W2045051162 hasBestOaLocation W20450511621 @default.
- W2045051162 hasConcept C104317684 @default.
- W2045051162 hasConcept C108249834 @default.
- W2045051162 hasConcept C127716648 @default.
- W2045051162 hasConcept C135763542 @default.
- W2045051162 hasConcept C147483822 @default.
- W2045051162 hasConcept C170627219 @default.
- W2045051162 hasConcept C180754005 @default.
- W2045051162 hasConcept C203014093 @default.
- W2045051162 hasConcept C207936829 @default.
- W2045051162 hasConcept C2776090121 @default.
- W2045051162 hasConcept C2780564577 @default.
- W2045051162 hasConcept C54355233 @default.
- W2045051162 hasConcept C67636389 @default.
- W2045051162 hasConcept C83464605 @default.
- W2045051162 hasConcept C86803240 @default.
- W2045051162 hasConcept C8891405 @default.
- W2045051162 hasConceptScore W2045051162C104317684 @default.
- W2045051162 hasConceptScore W2045051162C108249834 @default.
- W2045051162 hasConceptScore W2045051162C127716648 @default.
- W2045051162 hasConceptScore W2045051162C135763542 @default.
- W2045051162 hasConceptScore W2045051162C147483822 @default.
- W2045051162 hasConceptScore W2045051162C170627219 @default.
- W2045051162 hasConceptScore W2045051162C180754005 @default.
- W2045051162 hasConceptScore W2045051162C203014093 @default.
- W2045051162 hasConceptScore W2045051162C207936829 @default.
- W2045051162 hasConceptScore W2045051162C2776090121 @default.
- W2045051162 hasConceptScore W2045051162C2780564577 @default.
- W2045051162 hasConceptScore W2045051162C54355233 @default.
- W2045051162 hasConceptScore W2045051162C67636389 @default.
- W2045051162 hasConceptScore W2045051162C83464605 @default.
- W2045051162 hasConceptScore W2045051162C86803240 @default.
- W2045051162 hasConceptScore W2045051162C8891405 @default.
- W2045051162 hasIssue "6" @default.
- W2045051162 hasLocation W20450511621 @default.
- W2045051162 hasLocation W20450511622 @default.
- W2045051162 hasOpenAccess W2045051162 @default.
- W2045051162 hasPrimaryLocation W20450511621 @default.
- W2045051162 hasRelatedWork W1661038996 @default.
- W2045051162 hasRelatedWork W1680198589 @default.
- W2045051162 hasRelatedWork W2000941383 @default.
- W2045051162 hasRelatedWork W2057739827 @default.
- W2045051162 hasRelatedWork W2084632240 @default.
- W2045051162 hasRelatedWork W2094482300 @default.
- W2045051162 hasRelatedWork W2129946713 @default.
- W2045051162 hasRelatedWork W2223919059 @default.
- W2045051162 hasRelatedWork W2245876498 @default.
- W2045051162 hasRelatedWork W2403733398 @default.
- W2045051162 hasVolume "8" @default.
- W2045051162 isParatext "false" @default.
- W2045051162 isRetracted "false" @default.
- W2045051162 magId "2045051162" @default.
- W2045051162 workType "article" @default.